Morphological parameters associated with ruptured posterior communicating aneurysms.

The rupture risk of unruptured intracranial aneurysms is known to be dependent on the size of the aneurysm. However, the association of morphological characteristics with ruptured aneurysms has not been established in a systematic and location specific manner for the most common aneurysm locations....

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Autores principales:	Allen Ho, Ning Lin, Nareerat Charoenvimolphan, Mary Stanley, Kai U Frerichs, Arthur L Day, Rose Du
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7d9aaa829994dd59d8dd8308d7ec2c6
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spelling	oai:doaj.org-article:e7d9aaa829994dd59d8dd8308d7ec2c62021-11-18T08:23:25ZMorphological parameters associated with ruptured posterior communicating aneurysms.1932-620310.1371/journal.pone.0094837https://doaj.org/article/e7d9aaa829994dd59d8dd8308d7ec2c62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24733151/?tool=EBIhttps://doaj.org/toc/1932-6203The rupture risk of unruptured intracranial aneurysms is known to be dependent on the size of the aneurysm. However, the association of morphological characteristics with ruptured aneurysms has not been established in a systematic and location specific manner for the most common aneurysm locations. We evaluated posterior communicating artery (PCoA) aneurysms for morphological parameters associated with aneurysm rupture in that location. CT angiograms were evaluated to generate 3-D models of the aneurysms and surrounding vasculature. Univariate and multivariate analyses were performed to evaluate morphological parameters including aneurysm volume, aspect ratio, size ratio, distance to ICA bifurcation, aneurysm angle, vessel angles, flow angles, and vessel-to-vessel angles. From 2005-2012, 148 PCoA aneurysms were treated in a single institution. Preoperative CTAs from 63 patients (40 ruptured, 23 unruptured) were available and analyzed. Multivariate logistic regression revealed that smaller volume (p = 0.011), larger aneurysm neck diameter (0.048), and shorter ICA bifurcation to aneurysm distance (p = 0.005) were the most strongly associated with aneurysm rupture after adjusting for all other clinical and morphological variables. Multivariate subgroup analysis for patients with visualized PCoA demonstrated that larger neck diameter (p = 0.018) and shorter ICA bifurcation to aneurysm distance (p = 0.011) were significantly associated with rupture. Intracerebral hemorrhage was associated with smaller volume, larger maximum height, and smaller aneurysm angle, in addition to lateral projection, male sex, and lack of hypertension. We found that shorter ICA bifurcation to aneurysm distance is significantly associated with PCoA aneurysm rupture. This is a new physically intuitive parameter that can be measured easily and therefore be readily applied in clinical practice to aid in the evaluation of patients with PCoA aneurysms.Allen HoNing LinNareerat CharoenvimolphanMary StanleyKai U FrerichsArthur L DayRose DuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e94837 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Allen Ho Ning Lin Nareerat Charoenvimolphan Mary Stanley Kai U Frerichs Arthur L Day Rose Du Morphological parameters associated with ruptured posterior communicating aneurysms.
description	The rupture risk of unruptured intracranial aneurysms is known to be dependent on the size of the aneurysm. However, the association of morphological characteristics with ruptured aneurysms has not been established in a systematic and location specific manner for the most common aneurysm locations. We evaluated posterior communicating artery (PCoA) aneurysms for morphological parameters associated with aneurysm rupture in that location. CT angiograms were evaluated to generate 3-D models of the aneurysms and surrounding vasculature. Univariate and multivariate analyses were performed to evaluate morphological parameters including aneurysm volume, aspect ratio, size ratio, distance to ICA bifurcation, aneurysm angle, vessel angles, flow angles, and vessel-to-vessel angles. From 2005-2012, 148 PCoA aneurysms were treated in a single institution. Preoperative CTAs from 63 patients (40 ruptured, 23 unruptured) were available and analyzed. Multivariate logistic regression revealed that smaller volume (p = 0.011), larger aneurysm neck diameter (0.048), and shorter ICA bifurcation to aneurysm distance (p = 0.005) were the most strongly associated with aneurysm rupture after adjusting for all other clinical and morphological variables. Multivariate subgroup analysis for patients with visualized PCoA demonstrated that larger neck diameter (p = 0.018) and shorter ICA bifurcation to aneurysm distance (p = 0.011) were significantly associated with rupture. Intracerebral hemorrhage was associated with smaller volume, larger maximum height, and smaller aneurysm angle, in addition to lateral projection, male sex, and lack of hypertension. We found that shorter ICA bifurcation to aneurysm distance is significantly associated with PCoA aneurysm rupture. This is a new physically intuitive parameter that can be measured easily and therefore be readily applied in clinical practice to aid in the evaluation of patients with PCoA aneurysms.
format	article
author	Allen Ho Ning Lin Nareerat Charoenvimolphan Mary Stanley Kai U Frerichs Arthur L Day Rose Du
author_facet	Allen Ho Ning Lin Nareerat Charoenvimolphan Mary Stanley Kai U Frerichs Arthur L Day Rose Du
author_sort	Allen Ho
title	Morphological parameters associated with ruptured posterior communicating aneurysms.
title_short	Morphological parameters associated with ruptured posterior communicating aneurysms.
title_full	Morphological parameters associated with ruptured posterior communicating aneurysms.
title_fullStr	Morphological parameters associated with ruptured posterior communicating aneurysms.
title_full_unstemmed	Morphological parameters associated with ruptured posterior communicating aneurysms.
title_sort	morphological parameters associated with ruptured posterior communicating aneurysms.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/e7d9aaa829994dd59d8dd8308d7ec2c6
work_keys_str_mv	AT allenho morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT ninglin morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT nareeratcharoenvimolphan morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT marystanley morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT kaiufrerichs morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT arthurlday morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms AT rosedu morphologicalparametersassociatedwithrupturedposteriorcommunicatinganeurysms
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Morphological parameters associated with ruptured posterior communicating aneurysms.

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