Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation.

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation.

Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-κB-mediated gene expression. However, the monomeric Compound A-activated GR is unable to trigger glucocorticoid response element-regulated gene expressi...

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Autores principales: Ilse M Beck, Zuzanna J Drebert, Ruben Hoya-Arias, Ali A Bahar, Michael Devos, Dorien Clarisse, Sofie Desmet, Nadia Bougarne, Bart Ruttens, Valerie Gossye, Geertrui Denecker, Sam Lievens, Marc Bracke, Jan Tavernier, Wim Declercq, Kris Gevaert, Wim Vanden Berghe, Guy Haegeman, Karolien De Bosscher
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e7db32ca698446dba6bb65b1baa9d22c
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