Neuropsychiatric symptoms in untreated Parkinson’s disease

Neuropsychiatric symptoms in untreated Parkinson’s disease

Szabolcs Szatmari,1–3 Ben Min-Woo Illigens,4 Timo Siepmann,5,6 Alexandra Pinter,5,7 Annamaria Takats,8 Daniel Bereczki8 1Department of Neurology, Sibiu County Emergency Hospital, Sibiu, 22nd Department of Neurology, Targu Mures Emergency Clinical County Hospital, Targu Mures, Romania; 3J&...

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Autores principales: Szatmari S, Illigens BM, Siepmann T, Pinter A, Takats A, Bereczki D
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
neuropsychiatric symptoms
Parkinson's disease
untreated
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/e7db54b29a81403ab03d3aeb0d00ad09
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spelling oai:doaj.org-article:e7db54b29a81403ab03d3aeb0d00ad092021-12-02T03:17:36ZNeuropsychiatric symptoms in untreated Parkinson’s disease1178-2021https://doaj.org/article/e7db54b29a81403ab03d3aeb0d00ad092017-03-01T00:00:00Zhttps://www.dovepress.com/neuropsychiatric-symptoms-in-untreated-parkinsonrsquos-disease-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Szabolcs Szatmari,1–3 Ben Min-Woo Illigens,4 Timo Siepmann,5,6 Alexandra Pinter,5,7 Annamaria Takats,8 Daniel Bereczki8 1Department of Neurology, Sibiu County Emergency Hospital, Sibiu, 22nd Department of Neurology, Targu Mures Emergency Clinical County Hospital, Targu Mures, Romania; 3János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary; 4Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 5Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, 6Department of Neurology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany; 7Department of Family Medicine, 8Department of Neurology, Semmelweis University, Budapest, Hungary Abstract: Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment. Keywords: neuropsychiatric symptoms, Parkinson’s disease, untreatedSzatmari SIlligens BMSiepmann TPinter ATakats ABereczki DDove Medical Pressarticleneuropsychiatric symptomsParkinson's diseaseuntreatedNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 815-826 (2017)
institution DOAJ
collection DOAJ
language EN
topic neuropsychiatric symptoms
Parkinson's disease
untreated
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle neuropsychiatric symptoms
Parkinson's disease
untreated
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Szatmari S
Illigens BM
Siepmann T
Pinter A
Takats A
Bereczki D
Neuropsychiatric symptoms in untreated Parkinson’s disease
description Szabolcs Szatmari,1–3 Ben Min-Woo Illigens,4 Timo Siepmann,5,6 Alexandra Pinter,5,7 Annamaria Takats,8 Daniel Bereczki8 1Department of Neurology, Sibiu County Emergency Hospital, Sibiu, 22nd Department of Neurology, Targu Mures Emergency Clinical County Hospital, Targu Mures, Romania; 3János Szentágothai Doctoral School of Neurosciences, Semmelweis University, Budapest, Hungary; 4Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 5Center for Clinical Research and Management Education, Division of Health Care Sciences, Dresden International University, 6Department of Neurology, University Hospital Carl Gustav Carus, Technical University of Dresden, Dresden, Germany; 7Department of Family Medicine, 8Department of Neurology, Semmelweis University, Budapest, Hungary Abstract: Neuropsychiatric and cognitive symptoms are common in Parkinson’s disease (PD) and may precede and exceed motor symptoms as major factors impacting disease course and quality of life. Neuropsychiatric symptoms (NPS) in PD are various and are attributed to pathologic changes within multiple brain regions, to psychological stress, and to adverse effects of dopamine replacement therapy. Sleep disorders and mood symptoms such as apathy, depression, and anxiety may antedate the development of motor symptoms by years, while other NPS such as impulse control disorders, psychosis, and cognitive impairment are more common in later stages of the disease. Few studies report on NPS in the early, untreated phase of PD. We reviewed the current literature on NPS in PD with a focus on the early, drug-naive stages of PD. Among these early disease stages, premotor and early motor phases were separately addressed in our review, highlighting the underlying pathophysiological mechanisms as well as epidemiological characteristics, clinical features, risk factors, and available techniques of clinical assessment. Keywords: neuropsychiatric symptoms, Parkinson’s disease, untreated
format article
author Szatmari S
Illigens BM
Siepmann T
Pinter A
Takats A
Bereczki D
author_facet Szatmari S
Illigens BM
Siepmann T
Pinter A
Takats A
Bereczki D
author_sort Szatmari S
title Neuropsychiatric symptoms in untreated Parkinson’s disease
title_short Neuropsychiatric symptoms in untreated Parkinson’s disease
title_full Neuropsychiatric symptoms in untreated Parkinson’s disease
title_fullStr Neuropsychiatric symptoms in untreated Parkinson’s disease
title_full_unstemmed Neuropsychiatric symptoms in untreated Parkinson’s disease
title_sort neuropsychiatric symptoms in untreated parkinson’s disease
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/e7db54b29a81403ab03d3aeb0d00ad09
work_keys_str_mv AT szatmaris neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
AT illigensbm neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
AT siepmannt neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
AT pintera neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
AT takatsa neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
AT bereczkid neuropsychiatricsymptomsinuntreatedparkinsonrsquosdisease
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