Crystal structure of a lipin/Pah phosphatidic acid phosphatase
Lipin/Pah phosphatidic acid phosphatases generate diacylglycerol to regulate triglyceride synthesis and cellular signaling. Here authors determine structures of Tetrahymena thermophila Pah2 and identify an N-terminal amphipathic helix essential for membrane association.
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Auteurs principaux: | Valerie I. Khayyo, Reece M. Hoffmann, Huan Wang, Justin A. Bell, John E. Burke, Karen Reue, Michael V. Airola |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2020
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Sujets: | |
Accès en ligne: | https://doaj.org/article/e7dcb21670bd4693b4f6bcddbb95ec7f |
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