Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry

Abstract This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Birthe Stemplewitz, Robert Kromer, Eik Vettorazzi, Ute Hidding, Andreas Frings, Carsten Buhmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7df2f2b73e9478488b921f8355978c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7df2f2b73e9478488b921f8355978c7
record_format	dspace
spelling	oai:doaj.org-article:e7df2f2b73e9478488b921f8355978c72021-12-02T16:06:55ZRetinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry10.1038/s41598-017-05575-82045-2322https://doaj.org/article/e7df2f2b73e9478488b921f8355978c72017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05575-8https://doaj.org/toc/2045-2322Abstract This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power. Applying OCT, PSP patients showed a smaller RNFL thickness in the inferior nasal and inferior temporal areas. The macular volume and the thickness of the majority of macular sectors were reduced compared to controls. SLP data showed a thinner RNFL thickness and an increase in the NFI in PSP patients. Sensitivity and specificity to discriminate PSP patients from controls were higher applying SLP than SD-OCT. Retinal changes did not correlate with disease duration or severity in any OCT or SLP measurement. PSP seems to be associated with reduced thickness and volume of the macula and reduction of the RNFL, independent of disease duration or severity. Retinal imaging with SD-OCT and SLP might become an additional tool in PSP diagnosis.Birthe StemplewitzRobert KromerEik VettorazziUte HiddingAndreas FringsCarsten BuhmannNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Birthe Stemplewitz Robert Kromer Eik Vettorazzi Ute Hidding Andreas Frings Carsten Buhmann Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
description	Abstract This cross-sectional study compared the retinal morphology between patients with progressive supranuclear palsy (PSP) and healthy controls. (The retinal nerve fiber layer (RNFL) around the optic disc and the retina in the macular area of 22 PSP patients and 151 controls were investigated by spectral domain optical coherence tomography (SD-OCT). Additionally, the RNFL and the nerve fiber index (NFI) were measured by scanning laser polarimetry (SLP). Results of RNFL measurements with SD-OCT and SLP were compared to assess diagnostic discriminatory power. Applying OCT, PSP patients showed a smaller RNFL thickness in the inferior nasal and inferior temporal areas. The macular volume and the thickness of the majority of macular sectors were reduced compared to controls. SLP data showed a thinner RNFL thickness and an increase in the NFI in PSP patients. Sensitivity and specificity to discriminate PSP patients from controls were higher applying SLP than SD-OCT. Retinal changes did not correlate with disease duration or severity in any OCT or SLP measurement. PSP seems to be associated with reduced thickness and volume of the macula and reduction of the RNFL, independent of disease duration or severity. Retinal imaging with SD-OCT and SLP might become an additional tool in PSP diagnosis.
format	article
author	Birthe Stemplewitz Robert Kromer Eik Vettorazzi Ute Hidding Andreas Frings Carsten Buhmann
author_facet	Birthe Stemplewitz Robert Kromer Eik Vettorazzi Ute Hidding Andreas Frings Carsten Buhmann
author_sort	Birthe Stemplewitz
title	Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
title_short	Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
title_full	Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
title_fullStr	Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
title_full_unstemmed	Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
title_sort	retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e7df2f2b73e9478488b921f8355978c7
work_keys_str_mv	AT birthestemplewitz retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry AT robertkromer retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry AT eikvettorazzi retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry AT utehidding retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry AT andreasfrings retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry AT carstenbuhmann retinaldegenerationinprogressivesupranuclearpalsymeasuredbyopticalcoherencetomographyandscanninglaserpolarimetry
_version_	1718384813087391744

Retinal degeneration in progressive supranuclear palsy measured by optical coherence tomography and scanning laser polarimetry

Ejemplares similares