Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method

Improved In Vivo Delivery of Small RNA Based on the Calcium Phosphate Method

In the past few years, we have demonstrated the efficacy of a nanoparticle system, super carbonate apatite (sCA), for the in vivo delivery of siRNA/miRNA. Intravenous injection of sCA loaded with small RNAs results in safe, high tumor delivery in mouse models. To further improve the efficiency of tu...

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Autores principales: Xin Wu, Yuhki Yokoyama, Hidekazu Takahashi, Shihori Kouda, Hiroyuki Yamamoto, Jiaqi Wang, Yoshihiro Morimoto, Kazumasa Minami, Tsuyoshi Hata, Awad Shamma, Akira Inoue, Masahisa Ohtsuka, Satoshi Shibata, Shogo Kobayashi, Shuji Akai, Hirofumi Yamamoto
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
iNaD
siRNA
microRNA
calcium phosphate
PEG blending
cancer treatment
Medicine
R
Acceso en línea:https://doaj.org/article/e7e544c360f24339ba9edac8c7656425
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