Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus

Runyu Du, Na Wu, Ling Li Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Ling LiDepartment of Endocrinology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, She...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Du R, Wu N, Li L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dysregulated ncrna pregnancy disorder placental dysfunction pregnancy-related complications trophoblast dysfunction Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/e7e6b5a3b78a4e9bb56415448a083cdc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7e6b5a3b78a4e9bb56415448a083cdc
record_format	dspace
spelling	oai:doaj.org-article:e7e6b5a3b78a4e9bb56415448a083cdc2021-12-02T15:11:05ZAberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus1178-7007https://doaj.org/article/e7e6b5a3b78a4e9bb56415448a083cdc2021-08-01T00:00:00Zhttps://www.dovepress.com/aberrantly-expressed-non-coding-rnas-in-the-placenta-and-their-role-in-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Runyu Du, Na Wu, Ling Li Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Ling LiDepartment of Endocrinology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province, 110004, People’s Republic of ChinaTel +86 18940251181Fax +86 24-25944460Email liling8864@hotmail.comAbstract: Gestational diabetes mellitus (GDM), one of the most common complications during pregnancy, is associated with a high risk of short- and long-term adverse effects on the mother and offspring. Placenta-derived hormones and cytokines aggravate maternal insulin resistance (IR) during pregnancy, which in turn contribute to GDM. The hyperglycemia and IR in GDM result in aberrant placental structure and function adversely affecting fetal growth and well-being. Therefore, it is reasonable to assume that structural and functional alterations in the placenta contribute to the pathogenesis of GDM and GDM-related complications. Increasing evidence suggests that multiple non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are dysregulated in placentas of patients with GDM and linked to abnormal placental structure, metabolism, and function. Manipulation of ncRNA expression led to some key pathophysiological features of GDM, such as trophoblast dysfunction, changes in intracellular glucose metabolism, and inflammation. Moreover, placenta-specific ncRNAs may be potential diagnostic biomarkers and even therapeutic targets for GDM. This review summarizes data published on the involvement of aberrantly expressed placental ncRNAs in GDM and provides information on their role in the pathogenesis of GDM and GDM-associated complications.Keywords: dysregulated ncRNA, pregnancy disorder, placental dysfunction, pregnancy-related complications, trophoblast dysfunctionDu RWu NLi LDove Medical Pressarticledysregulated ncrnapregnancy disorderplacental dysfunctionpregnancy-related complicationstrophoblast dysfunctionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3719-3732 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dysregulated ncrna pregnancy disorder placental dysfunction pregnancy-related complications trophoblast dysfunction Specialties of internal medicine RC581-951
spellingShingle	dysregulated ncrna pregnancy disorder placental dysfunction pregnancy-related complications trophoblast dysfunction Specialties of internal medicine RC581-951 Du R Wu N Li L Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
description	Runyu Du, Na Wu, Ling Li Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Ling LiDepartment of Endocrinology, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province, 110004, People’s Republic of ChinaTel +86 18940251181Fax +86 24-25944460Email liling8864@hotmail.comAbstract: Gestational diabetes mellitus (GDM), one of the most common complications during pregnancy, is associated with a high risk of short- and long-term adverse effects on the mother and offspring. Placenta-derived hormones and cytokines aggravate maternal insulin resistance (IR) during pregnancy, which in turn contribute to GDM. The hyperglycemia and IR in GDM result in aberrant placental structure and function adversely affecting fetal growth and well-being. Therefore, it is reasonable to assume that structural and functional alterations in the placenta contribute to the pathogenesis of GDM and GDM-related complications. Increasing evidence suggests that multiple non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are dysregulated in placentas of patients with GDM and linked to abnormal placental structure, metabolism, and function. Manipulation of ncRNA expression led to some key pathophysiological features of GDM, such as trophoblast dysfunction, changes in intracellular glucose metabolism, and inflammation. Moreover, placenta-specific ncRNAs may be potential diagnostic biomarkers and even therapeutic targets for GDM. This review summarizes data published on the involvement of aberrantly expressed placental ncRNAs in GDM and provides information on their role in the pathogenesis of GDM and GDM-associated complications.Keywords: dysregulated ncRNA, pregnancy disorder, placental dysfunction, pregnancy-related complications, trophoblast dysfunction
format	article
author	Du R Wu N Li L
author_facet	Du R Wu N Li L
author_sort	Du R
title	Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
title_short	Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
title_full	Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
title_fullStr	Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
title_full_unstemmed	Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus
title_sort	aberrantly expressed non-coding rnas in the placenta and their role in the pathophysiology of gestational diabetes mellitus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/e7e6b5a3b78a4e9bb56415448a083cdc
work_keys_str_mv	AT dur aberrantlyexpressednoncodingrnasintheplacentaandtheirroleinthepathophysiologyofgestationaldiabetesmellitus AT wun aberrantlyexpressednoncodingrnasintheplacentaandtheirroleinthepathophysiologyofgestationaldiabetesmellitus AT lil aberrantlyexpressednoncodingrnasintheplacentaandtheirroleinthepathophysiologyofgestationaldiabetesmellitus
_version_	1718387666104352768

Aberrantly Expressed Non-Coding RNAs in the Placenta and Their Role in the Pathophysiology of Gestational Diabetes Mellitus

Ejemplares similares