Pain sensitivity in men who have never experienced a headache: an observer blinded case control study

Abstract Background Headache affects 90–99% of the population. Based on the question “Do you think that you never ever in your whole life have had a headache?” 4% of the population say that they have never experienced a headache. The rarity of never having had a headache suggests that distinct biolo...

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Autores principales:	Isa Amalie Olofsson, Jeppe Hvedstrup, Katrine Falkenberg, Mona Ameri Chalmer, Henrik Winther Schytz, Miguel Benjamin Pedersen, Henrik Ullum, Ole Birger Pedersen, Jes Olesen, Thomas Folkmann Hansen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Never headache Quantitative sensory testing Total tenderness score Cold pressor test Pain threshold Pain sensitivity Medicine R
Acceso en línea:	https://doaj.org/article/e7ead2c116464cf9bec1a067c924eb7f
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spelling	oai:doaj.org-article:e7ead2c116464cf9bec1a067c924eb7f2021-11-14T12:37:31ZPain sensitivity in men who have never experienced a headache: an observer blinded case control study10.1186/s10194-021-01345-01129-23691129-2377https://doaj.org/article/e7ead2c116464cf9bec1a067c924eb7f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s10194-021-01345-0https://doaj.org/toc/1129-2369https://doaj.org/toc/1129-2377Abstract Background Headache affects 90–99% of the population. Based on the question “Do you think that you never ever in your whole life have had a headache?” 4% of the population say that they have never experienced a headache. The rarity of never having had a headache suggests that distinct biological and environmental factors may be at play. We hypothesized that people who have never experienced a headache had a lower general pain sensitivity than controls. Methods We included 99 male participants, 47 headache free participants and 52 controls, in an observer blinded nested case-control study. We investigated cold pain threshold and heat pain threshold using a standardized quantitative sensory testing protocol, pericranial tenderness with total tenderness score and pain tolerance with the cold pressor test. Differences between the two groups were assessed with the unpaired Student’s t-test or Mann-Whitney U test as appropriate. Results There was no difference in age, weight or mean arterial pressure between headache free participants and controls. We found no difference in pain detection threshold, pericranial tenderness or pain tolerance between headache free participants and controls. Conclusion Our study clearly shows that freedom from headache is not caused by a lower general pain sensitivity. The results support the hypothesis that headache is caused by specific mechanisms, which are present in the primary headache disorders, rather than by a decreased general sensitivity to painful stimuli. Trial registration Registered at ClinicalTrials.gov ( NCT04217616 ), 3rd January 2020, retrospectively registered.Isa Amalie OlofssonJeppe HvedstrupKatrine FalkenbergMona Ameri ChalmerHenrik Winther SchytzMiguel Benjamin PedersenHenrik UllumOle Birger PedersenJes OlesenThomas Folkmann HansenBMCarticleNever headacheQuantitative sensory testingTotal tenderness scoreCold pressor testPain thresholdPain sensitivityMedicineRENThe Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Never headache Quantitative sensory testing Total tenderness score Cold pressor test Pain threshold Pain sensitivity Medicine R
spellingShingle	Never headache Quantitative sensory testing Total tenderness score Cold pressor test Pain threshold Pain sensitivity Medicine R Isa Amalie Olofsson Jeppe Hvedstrup Katrine Falkenberg Mona Ameri Chalmer Henrik Winther Schytz Miguel Benjamin Pedersen Henrik Ullum Ole Birger Pedersen Jes Olesen Thomas Folkmann Hansen Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
description	Abstract Background Headache affects 90–99% of the population. Based on the question “Do you think that you never ever in your whole life have had a headache?” 4% of the population say that they have never experienced a headache. The rarity of never having had a headache suggests that distinct biological and environmental factors may be at play. We hypothesized that people who have never experienced a headache had a lower general pain sensitivity than controls. Methods We included 99 male participants, 47 headache free participants and 52 controls, in an observer blinded nested case-control study. We investigated cold pain threshold and heat pain threshold using a standardized quantitative sensory testing protocol, pericranial tenderness with total tenderness score and pain tolerance with the cold pressor test. Differences between the two groups were assessed with the unpaired Student’s t-test or Mann-Whitney U test as appropriate. Results There was no difference in age, weight or mean arterial pressure between headache free participants and controls. We found no difference in pain detection threshold, pericranial tenderness or pain tolerance between headache free participants and controls. Conclusion Our study clearly shows that freedom from headache is not caused by a lower general pain sensitivity. The results support the hypothesis that headache is caused by specific mechanisms, which are present in the primary headache disorders, rather than by a decreased general sensitivity to painful stimuli. Trial registration Registered at ClinicalTrials.gov ( NCT04217616 ), 3rd January 2020, retrospectively registered.
format	article
author	Isa Amalie Olofsson Jeppe Hvedstrup Katrine Falkenberg Mona Ameri Chalmer Henrik Winther Schytz Miguel Benjamin Pedersen Henrik Ullum Ole Birger Pedersen Jes Olesen Thomas Folkmann Hansen
author_facet	Isa Amalie Olofsson Jeppe Hvedstrup Katrine Falkenberg Mona Ameri Chalmer Henrik Winther Schytz Miguel Benjamin Pedersen Henrik Ullum Ole Birger Pedersen Jes Olesen Thomas Folkmann Hansen
author_sort	Isa Amalie Olofsson
title	Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
title_short	Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
title_full	Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
title_fullStr	Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
title_full_unstemmed	Pain sensitivity in men who have never experienced a headache: an observer blinded case control study
title_sort	pain sensitivity in men who have never experienced a headache: an observer blinded case control study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e7ead2c116464cf9bec1a067c924eb7f
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Pain sensitivity in men who have never experienced a headache: an observer blinded case control study

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