Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection

Abstract The aim of this study was to analyze the role of blood biomarkers regarding preoperative inflammation and coagulation in predicting the postoperative in-hospital mortality of patients with type A acute aortic dissection (AAD). A total of 206 patients with type A AAD who had received surgica...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ming Li, Suochun Xu, Yang Yan, Haichen Wang, Jianjie Zheng, Yongxin Li, Yongjian Zhang, Junjun Hao, Chao Deng, Xinglong Zheng, Miaomiao Liu, Yang Gao, Xue Wang, Li Xue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7ed07b95d1d4dbc931b014dfe0ab09a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7ed07b95d1d4dbc931b014dfe0ab09a
record_format	dspace
spelling	oai:doaj.org-article:e7ed07b95d1d4dbc931b014dfe0ab09a2021-12-02T18:14:30ZAssociation of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection10.1038/s41598-021-98298-w2045-2322https://doaj.org/article/e7ed07b95d1d4dbc931b014dfe0ab09a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98298-whttps://doaj.org/toc/2045-2322Abstract The aim of this study was to analyze the role of blood biomarkers regarding preoperative inflammation and coagulation in predicting the postoperative in-hospital mortality of patients with type A acute aortic dissection (AAD). A total of 206 patients with type A AAD who had received surgical treatment were enrolled in this study. Patients were divided into two groups: the death group (28 patients who died during hospitalization) and the survival group (178 patients). Peripheral blood samples were collected before anesthesia induction. Preoperative levels of D-dimer, fibrinogen (FIB), platelet (PLT), white blood cells (WBC) and neutrophil (NEU) were compared between the two groups. Univariable and multivariable logistic regression analysis were utilized to identify the independent risk factors for postoperative in-hospital deaths of patients with type A AAD. Receiver operating characteristic (ROC) curve were used to analyze the predictive value of these indices in the postoperative in-hospital mortality of the patients. Univariable logistic regression analysis showed that the P values of the five parameters including D-dimer, FIB, PLT, WBC and NEU were all less than 0.1, which may be risk factors for postoperative in-hospital deaths of patients with type A AAD. Further multivariable logistic regression analysis indicated that higher preoperative D-dimer and WBC levels were independent risk factors for postoperative in-hospital mortality of patients with type A AAD. ROC curve analysis indicated that application of combining FIB and PLT could improve accuracy in prediction of postoperative in-hospital mortality in patients with type A AAD. Both preoperative D-dimer and WBC in patients with type A AAD may be used as independent risk factors for the postoperative in-hospital mortality of such patients. The combination of FIB and PLT may improve the accuracy of clinical prognostic assessment.Ming LiSuochun XuYang YanHaichen WangJianjie ZhengYongxin LiYongjian ZhangJunjun HaoChao DengXinglong ZhengMiaomiao LiuYang GaoXue WangLi XueNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ming Li Suochun Xu Yang Yan Haichen Wang Jianjie Zheng Yongxin Li Yongjian Zhang Junjun Hao Chao Deng Xinglong Zheng Miaomiao Liu Yang Gao Xue Wang Li Xue Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
description	Abstract The aim of this study was to analyze the role of blood biomarkers regarding preoperative inflammation and coagulation in predicting the postoperative in-hospital mortality of patients with type A acute aortic dissection (AAD). A total of 206 patients with type A AAD who had received surgical treatment were enrolled in this study. Patients were divided into two groups: the death group (28 patients who died during hospitalization) and the survival group (178 patients). Peripheral blood samples were collected before anesthesia induction. Preoperative levels of D-dimer, fibrinogen (FIB), platelet (PLT), white blood cells (WBC) and neutrophil (NEU) were compared between the two groups. Univariable and multivariable logistic regression analysis were utilized to identify the independent risk factors for postoperative in-hospital deaths of patients with type A AAD. Receiver operating characteristic (ROC) curve were used to analyze the predictive value of these indices in the postoperative in-hospital mortality of the patients. Univariable logistic regression analysis showed that the P values of the five parameters including D-dimer, FIB, PLT, WBC and NEU were all less than 0.1, which may be risk factors for postoperative in-hospital deaths of patients with type A AAD. Further multivariable logistic regression analysis indicated that higher preoperative D-dimer and WBC levels were independent risk factors for postoperative in-hospital mortality of patients with type A AAD. ROC curve analysis indicated that application of combining FIB and PLT could improve accuracy in prediction of postoperative in-hospital mortality in patients with type A AAD. Both preoperative D-dimer and WBC in patients with type A AAD may be used as independent risk factors for the postoperative in-hospital mortality of such patients. The combination of FIB and PLT may improve the accuracy of clinical prognostic assessment.
format	article
author	Ming Li Suochun Xu Yang Yan Haichen Wang Jianjie Zheng Yongxin Li Yongjian Zhang Junjun Hao Chao Deng Xinglong Zheng Miaomiao Liu Yang Gao Xue Wang Li Xue
author_facet	Ming Li Suochun Xu Yang Yan Haichen Wang Jianjie Zheng Yongxin Li Yongjian Zhang Junjun Hao Chao Deng Xinglong Zheng Miaomiao Liu Yang Gao Xue Wang Li Xue
author_sort	Ming Li
title	Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
title_short	Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
title_full	Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
title_fullStr	Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
title_full_unstemmed	Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection
title_sort	association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type a acute aortic dissection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7ed07b95d1d4dbc931b014dfe0ab09a
work_keys_str_mv	AT mingli associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT suochunxu associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT yangyan associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT haichenwang associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT jianjiezheng associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT yongxinli associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT yongjianzhang associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT junjunhao associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT chaodeng associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT xinglongzheng associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT miaomiaoliu associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT yanggao associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT xuewang associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection AT lixue associationofbiomarkersrelatedtopreoperativeinflammatoryandcoagulationwithpostoperativeinhospitaldeathsinpatientswithtypeaacuteaorticdissection
_version_	1718378427900231680

Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection

Ejemplares similares