Central amygdala micro-circuits mediate fear extinction

The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.

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Autores principales:	Nigel Whittle, Jonathan Fadok, Kathryn P. MacPherson, Robin Nguyen, Paolo Botta, Steffen B. E. Wolff, Christian Müller, Cyril Herry, Philip Tovote, Andrew Holmes, Nicolas Singewald, Andreas Lüthi, Stéphane Ciocchi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e7f5a40092e743959f493ea9a98ded5d
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spelling	oai:doaj.org-article:e7f5a40092e743959f493ea9a98ded5d2021-12-02T18:34:21ZCentral amygdala micro-circuits mediate fear extinction10.1038/s41467-021-24068-x2041-1723https://doaj.org/article/e7f5a40092e743959f493ea9a98ded5d2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24068-xhttps://doaj.org/toc/2041-1723The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.Nigel WhittleJonathan FadokKathryn P. MacPhersonRobin NguyenPaolo BottaSteffen B. E. WolffChristian MüllerCyril HerryPhilip TovoteAndrew HolmesNicolas SingewaldAndreas LüthiStéphane CiocchiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nigel Whittle Jonathan Fadok Kathryn P. MacPherson Robin Nguyen Paolo Botta Steffen B. E. Wolff Christian Müller Cyril Herry Philip Tovote Andrew Holmes Nicolas Singewald Andreas Lüthi Stéphane Ciocchi Central amygdala micro-circuits mediate fear extinction
description	The central amygdala inhibitory microcircuits mediate fear extinction by reversible, stimulus- and context-specific changes in neuronal responses. These alterations are absent when extinction is deficient and selective silencing of PKCδ neurons impairs fear extinction.
format	article
author	Nigel Whittle Jonathan Fadok Kathryn P. MacPherson Robin Nguyen Paolo Botta Steffen B. E. Wolff Christian Müller Cyril Herry Philip Tovote Andrew Holmes Nicolas Singewald Andreas Lüthi Stéphane Ciocchi
author_facet	Nigel Whittle Jonathan Fadok Kathryn P. MacPherson Robin Nguyen Paolo Botta Steffen B. E. Wolff Christian Müller Cyril Herry Philip Tovote Andrew Holmes Nicolas Singewald Andreas Lüthi Stéphane Ciocchi
author_sort	Nigel Whittle
title	Central amygdala micro-circuits mediate fear extinction
title_short	Central amygdala micro-circuits mediate fear extinction
title_full	Central amygdala micro-circuits mediate fear extinction
title_fullStr	Central amygdala micro-circuits mediate fear extinction
title_full_unstemmed	Central amygdala micro-circuits mediate fear extinction
title_sort	central amygdala micro-circuits mediate fear extinction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e7f5a40092e743959f493ea9a98ded5d
work_keys_str_mv	AT nigelwhittle centralamygdalamicrocircuitsmediatefearextinction AT jonathanfadok centralamygdalamicrocircuitsmediatefearextinction AT kathrynpmacpherson centralamygdalamicrocircuitsmediatefearextinction AT robinnguyen centralamygdalamicrocircuitsmediatefearextinction AT paolobotta centralamygdalamicrocircuitsmediatefearextinction AT steffenbewolff centralamygdalamicrocircuitsmediatefearextinction AT christianmuller centralamygdalamicrocircuitsmediatefearextinction AT cyrilherry centralamygdalamicrocircuitsmediatefearextinction AT philiptovote centralamygdalamicrocircuitsmediatefearextinction AT andrewholmes centralamygdalamicrocircuitsmediatefearextinction AT nicolassingewald centralamygdalamicrocircuitsmediatefearextinction AT andreasluthi centralamygdalamicrocircuitsmediatefearextinction AT stephaneciocchi centralamygdalamicrocircuitsmediatefearextinction
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Central amygdala micro-circuits mediate fear extinction

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