Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.

In order to comprehensively screen genetic variants leading to differential expression of the important human ABCB1 gene in the primary drug-metabolizing organ, ABCB1 mRNA expression levels were measured in 73 normal liver tissue samples from Chinese subjects. A set of Tag SNPs. were genotyped. In a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Weihua Shou, Dazhi Wang, Kaiyue Zhang, Beilan Wang, Zhimin Wang, Jinxiu Shi, Wei Huang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7f89663c2894a1ab9d26fc532ec6be3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e7f89663c2894a1ab9d26fc532ec6be3
record_format	dspace
spelling	oai:doaj.org-article:e7f89663c2894a1ab9d26fc532ec6be32021-11-18T08:13:48ZGene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.1932-620310.1371/journal.pone.0046295https://doaj.org/article/e7f89663c2894a1ab9d26fc532ec6be32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23050008/?tool=EBIhttps://doaj.org/toc/1932-6203In order to comprehensively screen genetic variants leading to differential expression of the important human ABCB1 gene in the primary drug-metabolizing organ, ABCB1 mRNA expression levels were measured in 73 normal liver tissue samples from Chinese subjects. A set of Tag SNPs. were genotyped. In addition, imputation was performed within a 500 kb region around the ABCB1 gene using the reference panels of 1,000 Genome project and HapMap III. Bayesian regression was used to assess the strength of associations by compute Bayes Factors for imputed SNPs. Through imputation and linkage disequilibrium analysis, the imputed loci rs28373093, rs1002205, rs1029421, rs2285647, and rs10235835, may represent independent and strong association signals. rs28373093, a polymorphism 1.5 kb upstream from the ABCB1 transcription start site, has the strongest association. 2677 G>A/T and 3435C>T confer a clear gene-dosage effect on ABCB1 mRNA expression. The systematic characterization of gene-wide common quantitative trait loci associated with ABCB1 mRNA expression in normal liver tissues would provide the candidate markers to ABCB1-relevant clinical phenotypes in Chinese population.Weihua ShouDazhi WangKaiyue ZhangBeilan WangZhimin WangJinxiu ShiWei HuangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e46295 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weihua Shou Dazhi Wang Kaiyue Zhang Beilan Wang Zhimin Wang Jinxiu Shi Wei Huang Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
description	In order to comprehensively screen genetic variants leading to differential expression of the important human ABCB1 gene in the primary drug-metabolizing organ, ABCB1 mRNA expression levels were measured in 73 normal liver tissue samples from Chinese subjects. A set of Tag SNPs. were genotyped. In addition, imputation was performed within a 500 kb region around the ABCB1 gene using the reference panels of 1,000 Genome project and HapMap III. Bayesian regression was used to assess the strength of associations by compute Bayes Factors for imputed SNPs. Through imputation and linkage disequilibrium analysis, the imputed loci rs28373093, rs1002205, rs1029421, rs2285647, and rs10235835, may represent independent and strong association signals. rs28373093, a polymorphism 1.5 kb upstream from the ABCB1 transcription start site, has the strongest association. 2677 G>A/T and 3435C>T confer a clear gene-dosage effect on ABCB1 mRNA expression. The systematic characterization of gene-wide common quantitative trait loci associated with ABCB1 mRNA expression in normal liver tissues would provide the candidate markers to ABCB1-relevant clinical phenotypes in Chinese population.
format	article
author	Weihua Shou Dazhi Wang Kaiyue Zhang Beilan Wang Zhimin Wang Jinxiu Shi Wei Huang
author_facet	Weihua Shou Dazhi Wang Kaiyue Zhang Beilan Wang Zhimin Wang Jinxiu Shi Wei Huang
author_sort	Weihua Shou
title	Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
title_short	Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
title_full	Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
title_fullStr	Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
title_full_unstemmed	Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.
title_sort	gene-wide characterization of common quantitative trait loci for abcb1 mrna expression in normal liver tissues in the chinese population.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/e7f89663c2894a1ab9d26fc532ec6be3
work_keys_str_mv	AT weihuashou genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT dazhiwang genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT kaiyuezhang genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT beilanwang genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT zhiminwang genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT jinxiushi genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation AT weihuang genewidecharacterizationofcommonquantitativetraitlociforabcb1mrnaexpressioninnormallivertissuesinthechinesepopulation
_version_	1718422079953436672

Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population.

Ejemplares similares