A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy

Abstract An on-chip transducer, for monitoring noninvasively the insulin bio-availability in real time after administration in clinical diabetology, is proposed. The bioavailability is assessed as insulin decrease in situ after administration by means of local impedance measurement. Inter-and-intra...

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Autores principales:	Pasquale Arpaia, Umberto Cesaro, Mirco Frosolone, Nicola Moccaldi, Maurizio Taglialatela
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7fc7851ec154676b636f8f884dbe56d
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spelling	oai:doaj.org-article:e7fc7851ec154676b636f8f884dbe56d2021-12-02T18:50:57ZA micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy10.1038/s41598-020-70376-52045-2322https://doaj.org/article/e7fc7851ec154676b636f8f884dbe56d2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-70376-5https://doaj.org/toc/2045-2322Abstract An on-chip transducer, for monitoring noninvasively the insulin bio-availability in real time after administration in clinical diabetology, is proposed. The bioavailability is assessed as insulin decrease in situ after administration by means of local impedance measurement. Inter-and-intra individual reproducibility is enhanced by a personalized model, specific for the subject, identified and validated during each insulin administration. Such a real-time noninvasive bioavailability measurement allows to increase the accuracy of insulin bolus administration, by attenuating drawbacks of glycemic swings significantly. In the first part of this paper, the concept, the architecture, and the operation of the transducer, as well as details about its prototype, are illustrated. Then, the metrological characterization and validation are reported in laboratory, in vitro on eggplants, ex vivo on pig abdominal non-perfused muscle, and in vivo on a human subject, using injection as a reference subcutaneous delivery of insulin. Results of significant intra-individual reproducibility in vitro and ex vivo point out noteworthy scenarios for assessing insulin bioavailability in clinical diabetology.Pasquale ArpaiaUmberto CesaroMirco FrosoloneNicola MoccaldiMaurizio TaglialatelaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pasquale Arpaia Umberto Cesaro Mirco Frosolone Nicola Moccaldi Maurizio Taglialatela A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
description	Abstract An on-chip transducer, for monitoring noninvasively the insulin bio-availability in real time after administration in clinical diabetology, is proposed. The bioavailability is assessed as insulin decrease in situ after administration by means of local impedance measurement. Inter-and-intra individual reproducibility is enhanced by a personalized model, specific for the subject, identified and validated during each insulin administration. Such a real-time noninvasive bioavailability measurement allows to increase the accuracy of insulin bolus administration, by attenuating drawbacks of glycemic swings significantly. In the first part of this paper, the concept, the architecture, and the operation of the transducer, as well as details about its prototype, are illustrated. Then, the metrological characterization and validation are reported in laboratory, in vitro on eggplants, ex vivo on pig abdominal non-perfused muscle, and in vivo on a human subject, using injection as a reference subcutaneous delivery of insulin. Results of significant intra-individual reproducibility in vitro and ex vivo point out noteworthy scenarios for assessing insulin bioavailability in clinical diabetology.
format	article
author	Pasquale Arpaia Umberto Cesaro Mirco Frosolone Nicola Moccaldi Maurizio Taglialatela
author_facet	Pasquale Arpaia Umberto Cesaro Mirco Frosolone Nicola Moccaldi Maurizio Taglialatela
author_sort	Pasquale Arpaia
title	A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
title_short	A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
title_full	A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
title_fullStr	A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
title_full_unstemmed	A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
title_sort	micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e7fc7851ec154676b636f8f884dbe56d
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A micro-bioimpedance meter for monitoring insulin bioavailability in personalized diabetes therapy

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