In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.

The acquisition of mitochondria was a key event in eukaryote evolution. The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamenta...

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Autores principales:	Ludovic Delage, Catherine Leblanc, Pi Nyvall Collén, Bernhard Gschloessl, Marie-Pierre Oudot, Lieven Sterck, Julie Poulain, Jean-Marc Aury, J Mark Cock
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e7fd12b495934c0a9ff91ad5f765b570
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spelling	oai:doaj.org-article:e7fd12b495934c0a9ff91ad5f765b5702021-11-18T06:53:47ZIn silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.1932-620310.1371/journal.pone.0019540https://doaj.org/article/e7fd12b495934c0a9ff91ad5f765b5702011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21611166/?tool=EBIhttps://doaj.org/toc/1932-6203The acquisition of mitochondria was a key event in eukaryote evolution. The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamental cellular process. Detailed searches were carried out both for components of the protein import system and for related peptidases. Comparative and phylogenetic analyses were used to investigate the evolution of mitochondrial proteins during eukaryote diversification. Key observations include phylogenetic evidence for very ancient origins for many protein import components (Tim21, Tim50, for example) and indications of differences between the outer membrane receptors that recognize the mitochondrial targeting signals, suggesting replacement, rearrangement and/or emergence of new components across the major eukaryotic lineages. Overall, the mitochondrial protein import components analysed in this study confirmed a high level of conservation during evolution, indicating that most are derived from very ancient, ancestral proteins. Several of the protein import components identified in Ectocarpus, such as Tim21, Tim50 and metaxin, have also been found in other stramenopiles and this study suggests an early origin during the evolution of the eukaryotes.Ludovic DelageCatherine LeblancPi Nyvall CollénBernhard GschloesslMarie-Pierre OudotLieven SterckJulie PoulainJean-Marc AuryJ Mark CockPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19540 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ludovic Delage Catherine Leblanc Pi Nyvall Collén Bernhard Gschloessl Marie-Pierre Oudot Lieven Sterck Julie Poulain Jean-Marc Aury J Mark Cock In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
description	The acquisition of mitochondria was a key event in eukaryote evolution. The aim of this study was to identify homologues of the components of the mitochondrial protein import machinery in the brown alga Ectocarpus and to use this information to investigate the evolutionary history of this fundamental cellular process. Detailed searches were carried out both for components of the protein import system and for related peptidases. Comparative and phylogenetic analyses were used to investigate the evolution of mitochondrial proteins during eukaryote diversification. Key observations include phylogenetic evidence for very ancient origins for many protein import components (Tim21, Tim50, for example) and indications of differences between the outer membrane receptors that recognize the mitochondrial targeting signals, suggesting replacement, rearrangement and/or emergence of new components across the major eukaryotic lineages. Overall, the mitochondrial protein import components analysed in this study confirmed a high level of conservation during evolution, indicating that most are derived from very ancient, ancestral proteins. Several of the protein import components identified in Ectocarpus, such as Tim21, Tim50 and metaxin, have also been found in other stramenopiles and this study suggests an early origin during the evolution of the eukaryotes.
format	article
author	Ludovic Delage Catherine Leblanc Pi Nyvall Collén Bernhard Gschloessl Marie-Pierre Oudot Lieven Sterck Julie Poulain Jean-Marc Aury J Mark Cock
author_facet	Ludovic Delage Catherine Leblanc Pi Nyvall Collén Bernhard Gschloessl Marie-Pierre Oudot Lieven Sterck Julie Poulain Jean-Marc Aury J Mark Cock
author_sort	Ludovic Delage
title	In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
title_short	In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
title_full	In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
title_fullStr	In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
title_full_unstemmed	In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.
title_sort	in silico survey of the mitochondrial protein uptake and maturation systems in the brown alga ectocarpus siliculosus.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/e7fd12b495934c0a9ff91ad5f765b570
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In silico survey of the mitochondrial protein uptake and maturation systems in the brown alga Ectocarpus siliculosus.

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