Clonal dynamics in osteosarcoma defined by RGB marking

Osteosarcoma is a heterogeneous bone tumour with a high mutational rate. Here the authors use an RGB-based single-cell tracking system to track clonal dynamics in a mouse model of osteosarcoma, which their findings indicate follows a neutral evolution model in which different clones simultaneously c...

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Autores principales: Stefano Gambera, Ander Abarrategi, Fernando González-Camacho, Álvaro Morales-Molina, Josep Roma, Arantzazu Alfranca, Javier García-Castro
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/e807f4b3ffa644a8a8fcdb65236ade01
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Sumario:Osteosarcoma is a heterogeneous bone tumour with a high mutational rate. Here the authors use an RGB-based single-cell tracking system to track clonal dynamics in a mouse model of osteosarcoma, which their findings indicate follows a neutral evolution model in which different clones simultaneously coexist and propagate.