NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma

Abstract Chromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and neck squamous cell carcinoma (HNSC) that features...

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Autores principales: Kevin Brennan, June Ho Shin, Joshua K. Tay, Marcos Prunello, Andrew J. Gentles, John B. Sunwoo, Olivier Gevaert
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/e80aabb014e14336a67aa59a1ef260a9
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