Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation

Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular neoplasm that requires long-term management. Several reports describe disseminated intravascular coagulation (DIC) associated with angiosarcoma, but no association with EHE has been reported. We encountered a patient with DIC compli...

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Autores principales:	Hiroaki Kimura, Norio Yamamoto, Katsuhiro Hayashi, Takashi Higuchi, Hiroyuki Tsuchiya
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	epithelioid hemangioendothelioma disseminated intravascular coagulation angiosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e80af2364980410fb95b04ae894ba9e6
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spelling	oai:doaj.org-article:e80af2364980410fb95b04ae894ba9e62021-11-18T11:08:46ZMultifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation1662-657510.1159/000519212https://doaj.org/article/e80af2364980410fb95b04ae894ba9e62021-10-01T00:00:00Zhttps://www.karger.com/Article/FullText/519212https://doaj.org/toc/1662-6575Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular neoplasm that requires long-term management. Several reports describe disseminated intravascular coagulation (DIC) associated with angiosarcoma, but no association with EHE has been reported. We encountered a patient with DIC complicated by multifocal EHE. The patient was an 83-year-old woman with spinal lesions, small lung nodules, and a soft tissue mass in the right buttock. The tumor was biopsied and diagnosed as EHE. The patient received pain control therapy without antitumor therapy. One month later, DIC developed with tumor progression. DIC subsided with nafamostat mesylate infusion, and oral apixaban was administered. DIC was managed for 5 months until the patient died of brain metastases. This is the first report of a patient with DIC complicated by EHE. It should be noted that progression of EHE can cause DIC. We were able to manage DIC using anticoagulant agents.Hiroaki KimuraNorio YamamotoKatsuhiro HayashiTakashi HiguchiHiroyuki TsuchiyaKarger Publishersarticleepithelioid hemangioendotheliomadisseminated intravascular coagulationangiosarcomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCase Reports in Oncology, Vol 14, Iss 3, Pp 1490-1496 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	epithelioid hemangioendothelioma disseminated intravascular coagulation angiosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	epithelioid hemangioendothelioma disseminated intravascular coagulation angiosarcoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hiroaki Kimura Norio Yamamoto Katsuhiro Hayashi Takashi Higuchi Hiroyuki Tsuchiya Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
description	Epithelioid hemangioendothelioma (EHE) is a rare malignant vascular neoplasm that requires long-term management. Several reports describe disseminated intravascular coagulation (DIC) associated with angiosarcoma, but no association with EHE has been reported. We encountered a patient with DIC complicated by multifocal EHE. The patient was an 83-year-old woman with spinal lesions, small lung nodules, and a soft tissue mass in the right buttock. The tumor was biopsied and diagnosed as EHE. The patient received pain control therapy without antitumor therapy. One month later, DIC developed with tumor progression. DIC subsided with nafamostat mesylate infusion, and oral apixaban was administered. DIC was managed for 5 months until the patient died of brain metastases. This is the first report of a patient with DIC complicated by EHE. It should be noted that progression of EHE can cause DIC. We were able to manage DIC using anticoagulant agents.
format	article
author	Hiroaki Kimura Norio Yamamoto Katsuhiro Hayashi Takashi Higuchi Hiroyuki Tsuchiya
author_facet	Hiroaki Kimura Norio Yamamoto Katsuhiro Hayashi Takashi Higuchi Hiroyuki Tsuchiya
author_sort	Hiroaki Kimura
title	Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
title_short	Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
title_full	Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
title_fullStr	Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
title_full_unstemmed	Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation
title_sort	multifocal epithelioid hemangioendothelioma complicated with disseminated intravascular coagulation
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/e80af2364980410fb95b04ae894ba9e6
work_keys_str_mv	AT hiroakikimura multifocalepithelioidhemangioendotheliomacomplicatedwithdisseminatedintravascularcoagulation AT norioyamamoto multifocalepithelioidhemangioendotheliomacomplicatedwithdisseminatedintravascularcoagulation AT katsuhirohayashi multifocalepithelioidhemangioendotheliomacomplicatedwithdisseminatedintravascularcoagulation AT takashihiguchi multifocalepithelioidhemangioendotheliomacomplicatedwithdisseminatedintravascularcoagulation AT hiroyukitsuchiya multifocalepithelioidhemangioendotheliomacomplicatedwithdisseminatedintravascularcoagulation
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Multifocal Epithelioid Hemangioendothelioma Complicated with Disseminated Intravascular Coagulation

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