Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo.

Lack of Matrilin-2 favors liver tumor development via Erk1/2 and GSK-3β pathways in vivo.

Matrilin-2 (Matn2) is a multidomain adaptor protein which plays a role in the assembly of extracellular matrix (ECM). It is produced by oval cells during stem cell-driven liver regeneration. In our study, the impact of Matn2 on hepatocarcinogenesis was investigated in Matn2(-/-) mice comparing them...

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Autores principales: Alexandra Fullár, Kornélia Baghy, Ferenc Deák, Bálint Péterfia, Yvonne Zsák, Péter Tátrai, Zsuzsa Schaff, József Dudás, Ibolya Kiss, Ilona Kovalszky
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e80dfd956d864a9686b67e0a730c2c23
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