Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy

CD19-negative relapses are observed in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 CAR-T cells. Here, by single-cell RNA sequencing of leukemic cells in a patient with B-ALL, the authors show that pre-existing CD19 negative leukemic subclones are present before C...

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Autores principales:	Tracy Rabilloud, Delphine Potier, Saran Pankaew, Mathis Nozais, Marie Loosveld, Dominique Payet-Bornet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e80e5847cd3a4941b39e3ec07ce22416
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spelling	oai:doaj.org-article:e80e5847cd3a4941b39e3ec07ce224162021-12-02T14:26:51ZSingle-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy10.1038/s41467-021-21168-62041-1723https://doaj.org/article/e80e5847cd3a4941b39e3ec07ce224162021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21168-6https://doaj.org/toc/2041-1723CD19-negative relapses are observed in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 CAR-T cells. Here, by single-cell RNA sequencing of leukemic cells in a patient with B-ALL, the authors show that pre-existing CD19 negative leukemic subclones are present before CAR-T cell therapy and can account for the relapse.Tracy RabilloudDelphine PotierSaran PankaewMathis NozaisMarie LoosveldDominique Payet-BornetNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tracy Rabilloud Delphine Potier Saran Pankaew Mathis Nozais Marie Loosveld Dominique Payet-Bornet Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
description	CD19-negative relapses are observed in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 CAR-T cells. Here, by single-cell RNA sequencing of leukemic cells in a patient with B-ALL, the authors show that pre-existing CD19 negative leukemic subclones are present before CAR-T cell therapy and can account for the relapse.
format	article
author	Tracy Rabilloud Delphine Potier Saran Pankaew Mathis Nozais Marie Loosveld Dominique Payet-Bornet
author_facet	Tracy Rabilloud Delphine Potier Saran Pankaew Mathis Nozais Marie Loosveld Dominique Payet-Bornet
author_sort	Tracy Rabilloud
title	Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
title_short	Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
title_full	Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
title_fullStr	Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
title_full_unstemmed	Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy
title_sort	single-cell profiling identifies pre-existing cd19-negative subclones in a b-all patient with cd19-negative relapse after car-t therapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e80e5847cd3a4941b39e3ec07ce22416
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Single-cell profiling identifies pre-existing CD19-negative subclones in a B-ALL patient with CD19-negative relapse after CAR-T therapy

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