Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling...

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Auteurs principaux:	N. Giovannone, J. Liang, A. Antonopoulos, J. Geddes Sweeney, S. L. King, S. M. Pochebit, N. Bhattacharyya, G. S. Lee, A. Dell, H. R. Widlund, S. M. Haslam, C. J. Dimitroff
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d
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spelling	oai:doaj.org-article:e80facbfd7b94762a3e41e78b109cc7d2021-12-02T16:56:58ZGalectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans10.1038/s41467-018-05770-92041-1723https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05770-9https://doaj.org/toc/2041-1723Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.N. GiovannoneJ. LiangA. AntonopoulosJ. Geddes SweeneyS. L. KingS. M. PochebitN. BhattacharyyaG. S. LeeA. DellH. R. WidlundS. M. HaslamC. J. DimitroffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q N. Giovannone J. Liang A. Antonopoulos J. Geddes Sweeney S. L. King S. M. Pochebit N. Bhattacharyya G. S. Lee A. Dell H. R. Widlund S. M. Haslam C. J. Dimitroff Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
description	Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.
format	article
author	N. Giovannone J. Liang A. Antonopoulos J. Geddes Sweeney S. L. King S. M. Pochebit N. Bhattacharyya G. S. Lee A. Dell H. R. Widlund S. M. Haslam C. J. Dimitroff
author_facet	N. Giovannone J. Liang A. Antonopoulos J. Geddes Sweeney S. L. King S. M. Pochebit N. Bhattacharyya G. S. Lee A. Dell H. R. Widlund S. M. Haslam C. J. Dimitroff
author_sort	N. Giovannone
title	Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_short	Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_full	Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_fullStr	Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_full_unstemmed	Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_sort	galectin-9 suppresses b cell receptor signaling and is regulated by i-branching of n-glycans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d
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Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

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