Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans

Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: N. Giovannone, J. Liang, A. Antonopoulos, J. Geddes Sweeney, S. L. King, S. M. Pochebit, N. Bhattacharyya, G. S. Lee, A. Dell, H. R. Widlund, S. M. Haslam, C. J. Dimitroff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e80facbfd7b94762a3e41e78b109cc7d
record_format dspace
spelling oai:doaj.org-article:e80facbfd7b94762a3e41e78b109cc7d2021-12-02T16:56:58ZGalectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans10.1038/s41467-018-05770-92041-1723https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05770-9https://doaj.org/toc/2041-1723Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.N. GiovannoneJ. LiangA. AntonopoulosJ. Geddes SweeneyS. L. KingS. M. PochebitN. BhattacharyyaG. S. LeeA. DellH. R. WidlundS. M. HaslamC. J. DimitroffNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
N. Giovannone
J. Liang
A. Antonopoulos
J. Geddes Sweeney
S. L. King
S. M. Pochebit
N. Bhattacharyya
G. S. Lee
A. Dell
H. R. Widlund
S. M. Haslam
C. J. Dimitroff
Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
description Leukocytes are coated with glycans that modulate immune function through interactions with lectins. Here, the authors characterize the N-glycan repertoire of human tonsillar B cells. They report that Gal-9 is an intrinsic regulator of B cell activation that may differentially modulate BCR signaling at steady state and within germinal centers due to expression of I-branched glycans.
format article
author N. Giovannone
J. Liang
A. Antonopoulos
J. Geddes Sweeney
S. L. King
S. M. Pochebit
N. Bhattacharyya
G. S. Lee
A. Dell
H. R. Widlund
S. M. Haslam
C. J. Dimitroff
author_facet N. Giovannone
J. Liang
A. Antonopoulos
J. Geddes Sweeney
S. L. King
S. M. Pochebit
N. Bhattacharyya
G. S. Lee
A. Dell
H. R. Widlund
S. M. Haslam
C. J. Dimitroff
author_sort N. Giovannone
title Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_short Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_full Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_fullStr Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_full_unstemmed Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans
title_sort galectin-9 suppresses b cell receptor signaling and is regulated by i-branching of n-glycans
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/e80facbfd7b94762a3e41e78b109cc7d
work_keys_str_mv AT ngiovannone galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT jliang galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT aantonopoulos galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT jgeddessweeney galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT slking galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT smpochebit galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT nbhattacharyya galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT gslee galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT adell galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT hrwidlund galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT smhaslam galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
AT cjdimitroff galectin9suppressesbcellreceptorsignalingandisregulatedbyibranchingofnglycans
_version_ 1718382713317097472

Ejemplares similares