Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

Abstract Breast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is us...

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Autores principales:	Wan Fatin Amira Wan Mohd Zawawi, M. H. Hibma, M. I. Salim, K. Jemon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e8176763d1f146a08636ba3dfa394456
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spelling	oai:doaj.org-article:e8176763d1f146a08636ba3dfa3944562021-12-02T15:55:13ZHyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor10.1038/s41598-021-89740-02045-2322https://doaj.org/article/e8176763d1f146a08636ba3dfa3944562021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89740-0https://doaj.org/toc/2045-2322Abstract Breast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is used for local hyperthermia, typically as an adjuvant to other cancer therapies. The understanding of the use of near NIR as a monotherapy, and its effects on the immune cells activation and infiltration, are limited. In this study, we investigate the effects of HT treatment using NIR on tumor regression and on the immune cells and molecules in breast tumors. Results from this study demonstrated that local HT by NIR at 43 °C reduced tumor progression and significantly increased the median survival of tumor-bearing mice. Immunohistochemical analysis revealed a significant reduction in cells proliferation in treated tumor, which was accompanied by an abundance of heat shock protein 70 (Hsp70). Increased numbers of activated dendritic cells were observed in the draining lymph nodes of the mice, along with infiltration of T cells, NK cells and B cells into the tumor. In contrast, tumor-infiltrated regulatory T cells were largely diminished from the tumor. In addition, higher IFN-γ and IL-2 secretion was observed in tumor of treated mice. Overall, results from this present study extends the understanding of using local HT by NIR to stimulate a favourable immune response against breast cancer.Wan Fatin Amira Wan Mohd ZawawiM. H. HibmaM. I. SalimK. JemonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wan Fatin Amira Wan Mohd Zawawi M. H. Hibma M. I. Salim K. Jemon Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
description	Abstract Breast cancer is the most common cancer that causes death in women. Conventional therapies, including surgery and chemotherapy, have different therapeutic effects and are commonly associated with risks and side effects. Near infrared radiation is a technique with few side effects that is used for local hyperthermia, typically as an adjuvant to other cancer therapies. The understanding of the use of near NIR as a monotherapy, and its effects on the immune cells activation and infiltration, are limited. In this study, we investigate the effects of HT treatment using NIR on tumor regression and on the immune cells and molecules in breast tumors. Results from this study demonstrated that local HT by NIR at 43 °C reduced tumor progression and significantly increased the median survival of tumor-bearing mice. Immunohistochemical analysis revealed a significant reduction in cells proliferation in treated tumor, which was accompanied by an abundance of heat shock protein 70 (Hsp70). Increased numbers of activated dendritic cells were observed in the draining lymph nodes of the mice, along with infiltration of T cells, NK cells and B cells into the tumor. In contrast, tumor-infiltrated regulatory T cells were largely diminished from the tumor. In addition, higher IFN-γ and IL-2 secretion was observed in tumor of treated mice. Overall, results from this present study extends the understanding of using local HT by NIR to stimulate a favourable immune response against breast cancer.
format	article
author	Wan Fatin Amira Wan Mohd Zawawi M. H. Hibma M. I. Salim K. Jemon
author_facet	Wan Fatin Amira Wan Mohd Zawawi M. H. Hibma M. I. Salim K. Jemon
author_sort	Wan Fatin Amira Wan Mohd Zawawi
title	Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
title_short	Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
title_full	Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
title_fullStr	Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
title_full_unstemmed	Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
title_sort	hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8176763d1f146a08636ba3dfa394456
work_keys_str_mv	AT wanfatinamirawanmohdzawawi hyperthermiabynearinfraredradiationinducedimmunecellsactivationandinfiltrationinbreasttumor AT mhhibma hyperthermiabynearinfraredradiationinducedimmunecellsactivationandinfiltrationinbreasttumor AT misalim hyperthermiabynearinfraredradiationinducedimmunecellsactivationandinfiltrationinbreasttumor AT kjemon hyperthermiabynearinfraredradiationinducedimmunecellsactivationandinfiltrationinbreasttumor
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Hyperthermia by near infrared radiation induced immune cells activation and infiltration in breast tumor

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