MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling

Abdominal aortic aneurysms (AAA) are a complex disease with an unclear pathomechanism. A positive family history is emphasized as a significant risk factor, and a nonspecific model of inheritance suggests participation of epigenetic regulation in the pathogenesis of this disease. Past studies have i...

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Autores principales:	Sabina Lichołai, Dorota Studzińska, Hanna Plutecka, Tomasz Gubała, Wojciech Szczeklik, Marek Sanak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	abdominal aortic aneurysms microRNA endothelial dysfunction Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e81b8cbfeb7948da88b7c72efa6cac54
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spelling	oai:doaj.org-article:e81b8cbfeb7948da88b7c72efa6cac542021-11-25T16:52:47ZMiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling10.3390/biom111116112218-273Xhttps://doaj.org/article/e81b8cbfeb7948da88b7c72efa6cac542021-10-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1611https://doaj.org/toc/2218-273XAbdominal aortic aneurysms (AAA) are a complex disease with an unclear pathomechanism. A positive family history is emphasized as a significant risk factor, and a nonspecific model of inheritance suggests participation of epigenetic regulation in the pathogenesis of this disease. Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. We found that miR-191 levels were significantly elevated in aneurysmal patients, although this did not correlate with the available clinical data. We then developed an in vitro model where, using cells with an endothelial phenotype, we determined the effect of miR-191 on the transcriptome using RNA sequencing. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms.Sabina LichołaiDorota StudzińskaHanna PluteckaTomasz GubałaWojciech SzczeklikMarek SanakMDPI AGarticleabdominal aortic aneurysmsmicroRNAendothelial dysfunctionMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1611, p 1611 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	abdominal aortic aneurysms microRNA endothelial dysfunction Microbiology QR1-502
spellingShingle	abdominal aortic aneurysms microRNA endothelial dysfunction Microbiology QR1-502 Sabina Lichołai Dorota Studzińska Hanna Plutecka Tomasz Gubała Wojciech Szczeklik Marek Sanak MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
description	Abdominal aortic aneurysms (AAA) are a complex disease with an unclear pathomechanism. A positive family history is emphasized as a significant risk factor, and a nonspecific model of inheritance suggests participation of epigenetic regulation in the pathogenesis of this disease. Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. We found that miR-191 levels were significantly elevated in aneurysmal patients, although this did not correlate with the available clinical data. We then developed an in vitro model where, using cells with an endothelial phenotype, we determined the effect of miR-191 on the transcriptome using RNA sequencing. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms.
format	article
author	Sabina Lichołai Dorota Studzińska Hanna Plutecka Tomasz Gubała Wojciech Szczeklik Marek Sanak
author_facet	Sabina Lichołai Dorota Studzińska Hanna Plutecka Tomasz Gubała Wojciech Szczeklik Marek Sanak
author_sort	Sabina Lichołai
title	MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
title_short	MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
title_full	MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
title_fullStr	MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
title_full_unstemmed	MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling
title_sort	mir-191 as a key molecule in aneurysmal aortic remodeling
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e81b8cbfeb7948da88b7c72efa6cac54
work_keys_str_mv	AT sabinalichołai mir191asakeymoleculeinaneurysmalaorticremodeling AT dorotastudzinska mir191asakeymoleculeinaneurysmalaorticremodeling AT hannaplutecka mir191asakeymoleculeinaneurysmalaorticremodeling AT tomaszgubała mir191asakeymoleculeinaneurysmalaorticremodeling AT wojciechszczeklik mir191asakeymoleculeinaneurysmalaorticremodeling AT mareksanak mir191asakeymoleculeinaneurysmalaorticremodeling
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MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling

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