Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of conventional versus autoreactive T-cell responses...

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Autores principales:	Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f
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spelling	oai:doaj.org-article:e81be3fdce5148d7897e24bc26448b4f2021-12-02T16:51:42ZPotassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions10.1038/ncomms146442041-1723https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14644https://doaj.org/toc/2041-1723Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of conventional versus autoreactive T-cell responses.Eugene Y. ChiangTianbo LiSurinder JeetIvan PengJuan ZhangWyne P. LeeJason DeVossPatrick CaplaziJun ChenSøren WarmingDavid H. HackosSusmith MukundChristopher M. KothJane L. GroganNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eugene Y. Chiang Tianbo Li Surinder Jeet Ivan Peng Juan Zhang Wyne P. Lee Jason DeVoss Patrick Caplazi Jun Chen Søren Warming David H. Hackos Susmith Mukund Christopher M. Koth Jane L. Grogan Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
description	Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of conventional versus autoreactive T-cell responses.
format	article
author	Eugene Y. Chiang Tianbo Li Surinder Jeet Ivan Peng Juan Zhang Wyne P. Lee Jason DeVoss Patrick Caplazi Jun Chen Søren Warming David H. Hackos Susmith Mukund Christopher M. Koth Jane L. Grogan
author_facet	Eugene Y. Chiang Tianbo Li Surinder Jeet Ivan Peng Juan Zhang Wyne P. Lee Jason DeVoss Patrick Caplazi Jun Chen Søren Warming David H. Hackos Susmith Mukund Christopher M. Koth Jane L. Grogan
author_sort	Eugene Y. Chiang
title	Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
title_short	Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
title_full	Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
title_fullStr	Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
title_full_unstemmed	Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
title_sort	potassium channels kv1.3 and kca3.1 cooperatively and compensatorily regulate antigen-specific memory t cell functions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f
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Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

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