Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of conventional versus autoreactive T-cell responses...

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Auteurs principaux: Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f
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https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f

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