[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie

Objective: To evaluate the efficacy of treatment based on the direct injection of verapamil into the plaque in patients with induratio penis plastica (IPP). Methods: In all, 21 patients with IPP were included. The mean patient age was 65.3 years. The plaques were found at the dorsum of the penis; th...

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Autores principales:	Marek Broul, Jan Schraml, Petra Hokuvova
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/e81e3af637374731ace823b9c3d79566
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spelling	oai:doaj.org-article:e81e3af637374731ace823b9c3d795662021-12-02T12:02:03Z[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie2090-598X10.1016/j.aju.2018.10.033https://doaj.org/article/e81e3af637374731ace823b9c3d795662018-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X1830127Xhttps://doaj.org/toc/2090-598XObjective: To evaluate the efficacy of treatment based on the direct injection of verapamil into the plaque in patients with induratio penis plastica (IPP). Methods: In all, 21 patients with IPP were included. The mean patient age was 65.3 years. The plaques were found at the dorsum of the penis; the mean deviation of the penis when erect was 52° and the mean size of the plaque was 8.5 mm. Erectile function was evaluated using the five-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Results: The mean IIEF-5 score was 11.9. The injection itself was reported to be relatively painless by all the patients. The patients rated pain using a visual analogue scale (VAS) with scores of 1 or 2. Two patients (9.5%) reported a haematoma of the penis’ skin after one of a series of injections. There were no severe complications. The efficacy of the therapy was assessed 2 or 3 months after the last injection. Both objective and subjective improvements were found in 14 men (66.6%). The penis deviation was lowered to 26.5° in 48% of cases. The size of the plaque was lowered to 5.2 mm in 33.7% of cases and the IIEF-5 questionnaire scored 15.9 points in 29.3% of cases. Conclusion: It is understood that the group of 21 patients is too small to properly evaluate the efficacy of the treatment. The long-term experience at our workplace indicates that treatment using injections of verapamil results in similar efficacy as treatment using extracorporeal shockwaves. Our findings show, that the injection of verapamil is an efficient and safe method. A significant number of patients report an improvement of their sexual health. The method is thus classed as a routine method of conservative treatment for IPP.Marek BroulJan SchramlPetra HokuvovaTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss , Pp S37-S38 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Marek Broul Jan Schraml Petra Hokuvova [80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
description	Objective: To evaluate the efficacy of treatment based on the direct injection of verapamil into the plaque in patients with induratio penis plastica (IPP). Methods: In all, 21 patients with IPP were included. The mean patient age was 65.3 years. The plaques were found at the dorsum of the penis; the mean deviation of the penis when erect was 52° and the mean size of the plaque was 8.5 mm. Erectile function was evaluated using the five-item version of the International Index of Erectile Function (IIEF-5) questionnaire. Results: The mean IIEF-5 score was 11.9. The injection itself was reported to be relatively painless by all the patients. The patients rated pain using a visual analogue scale (VAS) with scores of 1 or 2. Two patients (9.5%) reported a haematoma of the penis’ skin after one of a series of injections. There were no severe complications. The efficacy of the therapy was assessed 2 or 3 months after the last injection. Both objective and subjective improvements were found in 14 men (66.6%). The penis deviation was lowered to 26.5° in 48% of cases. The size of the plaque was lowered to 5.2 mm in 33.7% of cases and the IIEF-5 questionnaire scored 15.9 points in 29.3% of cases. Conclusion: It is understood that the group of 21 patients is too small to properly evaluate the efficacy of the treatment. The long-term experience at our workplace indicates that treatment using injections of verapamil results in similar efficacy as treatment using extracorporeal shockwaves. Our findings show, that the injection of verapamil is an efficient and safe method. A significant number of patients report an improvement of their sexual health. The method is thus classed as a routine method of conservative treatment for IPP.
format	article
author	Marek Broul Jan Schraml Petra Hokuvova
author_facet	Marek Broul Jan Schraml Petra Hokuvova
author_sort	Marek Broul
title	[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
title_short	[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
title_full	[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
title_fullStr	[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
title_full_unstemmed	[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie
title_sort	[80] injection of verapamil into the plaque of patients with induratio penis plastica (ipp) – morbus peyronie
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/e81e3af637374731ace823b9c3d79566
work_keys_str_mv	AT marekbroul 80injectionofverapamilintotheplaqueofpatientswithinduratiopenisplasticaippmorbuspeyronie AT janschraml 80injectionofverapamilintotheplaqueofpatientswithinduratiopenisplasticaippmorbuspeyronie AT petrahokuvova 80injectionofverapamilintotheplaqueofpatientswithinduratiopenisplasticaippmorbuspeyronie
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[80] Injection of verapamil into the plaque of patients with induratio penis plastica (IPP) – Morbus Peyronie

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