Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain

Abstract Maladaptive adult neurogenesis in the mammalian brain has been associated with diverse behaviors including disrupted learning, negative mood disorders and psychiatric conditions. However, its functional role in the generation and maintenance of chronic pathological pain has not yet been elu...

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Autores principales:	Linette Liqi Tan, Julieta Alfonso, Hannah Monyer, Rohini Kuner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e81ee295ee714445802db8c51827acb9
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spelling	oai:doaj.org-article:e81ee295ee714445802db8c51827acb92021-12-02T18:02:31ZNeurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain10.1038/s41598-021-97093-x2045-2322https://doaj.org/article/e81ee295ee714445802db8c51827acb92021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97093-xhttps://doaj.org/toc/2045-2322Abstract Maladaptive adult neurogenesis in the mammalian brain has been associated with diverse behaviors including disrupted learning, negative mood disorders and psychiatric conditions. However, its functional role in the generation and maintenance of chronic pathological pain has not yet been elucidated. Using an inducible genetic deletion in vivo mouse model, different behavioural paradigms and home cage monitoring systems, we show that an absence of adult neurogenesis does not impact the development of neuropathic injury-induced peripheral nociceptive hypersensitivity, but rather promotes the recovery of pathological pain as well as improves parameters associated with the state of well-being of the injured mice. These results provide a mechanistic insight into the mechanisms of chronic pain and implicate neurogenic processes as a potential therapeutic target for reducing pain and improving the quality of life for patients.Linette Liqi TanJulieta AlfonsoHannah MonyerRohini KunerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Linette Liqi Tan Julieta Alfonso Hannah Monyer Rohini Kuner Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
description	Abstract Maladaptive adult neurogenesis in the mammalian brain has been associated with diverse behaviors including disrupted learning, negative mood disorders and psychiatric conditions. However, its functional role in the generation and maintenance of chronic pathological pain has not yet been elucidated. Using an inducible genetic deletion in vivo mouse model, different behavioural paradigms and home cage monitoring systems, we show that an absence of adult neurogenesis does not impact the development of neuropathic injury-induced peripheral nociceptive hypersensitivity, but rather promotes the recovery of pathological pain as well as improves parameters associated with the state of well-being of the injured mice. These results provide a mechanistic insight into the mechanisms of chronic pain and implicate neurogenic processes as a potential therapeutic target for reducing pain and improving the quality of life for patients.
format	article
author	Linette Liqi Tan Julieta Alfonso Hannah Monyer Rohini Kuner
author_facet	Linette Liqi Tan Julieta Alfonso Hannah Monyer Rohini Kuner
author_sort	Linette Liqi Tan
title	Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
title_short	Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
title_full	Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
title_fullStr	Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
title_full_unstemmed	Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
title_sort	neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e81ee295ee714445802db8c51827acb9
work_keys_str_mv	AT linetteliqitan neurogenesisintheadultbrainfunctionallycontributestothemaintenanceofchronicneuropathicpain AT julietaalfonso neurogenesisintheadultbrainfunctionallycontributestothemaintenanceofchronicneuropathicpain AT hannahmonyer neurogenesisintheadultbrainfunctionallycontributestothemaintenanceofchronicneuropathicpain AT rohinikuner neurogenesisintheadultbrainfunctionallycontributestothemaintenanceofchronicneuropathicpain
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Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain

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