The effect of immune selection on the structure of the meningococcal opa protein repertoire.
The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large...
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Public Library of Science (PLoS)
2008
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oai:doaj.org-article:e81f5b20976c4bdfaec496834502c6732021-12-02T19:59:50ZThe effect of immune selection on the structure of the meningococcal opa protein repertoire.1553-73661553-737410.1371/journal.ppat.1000020https://doaj.org/article/e81f5b20976c4bdfaec496834502c6732008-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18369470/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire structure in a large, well-characterised collection of asymptomatically carried meningococci. Our data show an association between Opa repertoire and meningococcal lineages similar to that observed previously for meningococci isolated from cases of invasive disease. Furthermore, these Opa repertoires exhibit discrete, non-overlapping structure at a population level, and yet low within-repertoire diversity. These data are consistent with the predictions of a mathematical model of strong immune selection upon a system where identical alleles may occupy different loci.Martin J CallaghanCaroline O BuckeeKeith A JolleyPaula KrizMartin C J MaidenSunetra GuptaPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 4, Iss 3, p e1000020 (2008) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Martin J Callaghan Caroline O Buckee Keith A Jolley Paula Kriz Martin C J Maiden Sunetra Gupta The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| description |
The opa genes of the Gram negative bacterium Neisseria meningitidis encode Opacity-associated outer membrane proteins whose role is to promote adhesion to the human host tissue during colonisation and invasion. Each meningococcus contains 3-4 opa loci, each of which may be occupied by one of a large number of alleles. We analysed the Opa repertoire structure in a large, well-characterised collection of asymptomatically carried meningococci. Our data show an association between Opa repertoire and meningococcal lineages similar to that observed previously for meningococci isolated from cases of invasive disease. Furthermore, these Opa repertoires exhibit discrete, non-overlapping structure at a population level, and yet low within-repertoire diversity. These data are consistent with the predictions of a mathematical model of strong immune selection upon a system where identical alleles may occupy different loci. |
| format |
article |
| author |
Martin J Callaghan Caroline O Buckee Keith A Jolley Paula Kriz Martin C J Maiden Sunetra Gupta |
| author_facet |
Martin J Callaghan Caroline O Buckee Keith A Jolley Paula Kriz Martin C J Maiden Sunetra Gupta |
| author_sort |
Martin J Callaghan |
| title |
The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| title_short |
The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| title_full |
The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| title_fullStr |
The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| title_full_unstemmed |
The effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| title_sort |
effect of immune selection on the structure of the meningococcal opa protein repertoire. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2008 |
| url |
https://doaj.org/article/e81f5b20976c4bdfaec496834502c673 |
| work_keys_str_mv |
AT martinjcallaghan theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT carolineobuckee theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT keithajolley theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT paulakriz theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT martincjmaiden theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT sunetragupta theeffectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT martinjcallaghan effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT carolineobuckee effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT keithajolley effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT paulakriz effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT martincjmaiden effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire AT sunetragupta effectofimmuneselectiononthestructureofthemeningococcalopaproteinrepertoire |
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1718375754781163520 |