Type I hypersensitivity promotes Aedes aegypti blood feeding

Abstract Mosquitoes play a major role in human disease by serving as vectors of pathogenic microorganisms. Mosquitoes inject saliva into host skin during the probing process. Mosquito saliva contains a number of proteins that facilitate blood feeding by preventing hemostasis. Mosquito saliva also co...

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Autor principal:	Michael J. Conway
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e82076ca08554391ad1f34a139e3bea5
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spelling	oai:doaj.org-article:e82076ca08554391ad1f34a139e3bea52021-12-02T16:17:34ZType I hypersensitivity promotes Aedes aegypti blood feeding10.1038/s41598-021-94416-w2045-2322https://doaj.org/article/e82076ca08554391ad1f34a139e3bea52021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94416-whttps://doaj.org/toc/2045-2322Abstract Mosquitoes play a major role in human disease by serving as vectors of pathogenic microorganisms. Mosquitoes inject saliva into host skin during the probing process. Mosquito saliva contains a number of proteins that facilitate blood feeding by preventing hemostasis. Mosquito saliva also contains potent allergens that induce type I hypersensitivity reactions in some individuals. Type I hypersensitivity reactions in skin involve IgE-mediated degranulation of mast cells, which leads to vasodilation and an itch sensation. We hypothesized that hypersensitivity to mosquito saliva influences blood feeding. To test this hypothesis, we recruited human subjects who consented to Aedes aegypti bites. We measured their first sensation of itch, the strength of their itch sensation, the number of times mosquitoes attempted to feed, the number of times mosquitoes probed their skin, feeding time, engorgement status, and wheal diameter. Here we show that hypersensitive subjects had a stronger itch sensation, and that the time to first itch sensation was inversely correlated with wheal diameter; however, mosquitoes tended to probe less and engorge more on these subjects. Follow-up experiments testing the impact of oral antihistamine treatment on mosquito feeding parameters failed to reveal a statistically significant result. Histamine also failed to promote blood feeding on an artificial membrane feeder. This study suggests that mosquito saliva-induced type I hypersensitivity promotes blood feeding but that this may be independent from histamine or histamine signaling.Michael J. ConwayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael J. Conway Type I hypersensitivity promotes Aedes aegypti blood feeding
description	Abstract Mosquitoes play a major role in human disease by serving as vectors of pathogenic microorganisms. Mosquitoes inject saliva into host skin during the probing process. Mosquito saliva contains a number of proteins that facilitate blood feeding by preventing hemostasis. Mosquito saliva also contains potent allergens that induce type I hypersensitivity reactions in some individuals. Type I hypersensitivity reactions in skin involve IgE-mediated degranulation of mast cells, which leads to vasodilation and an itch sensation. We hypothesized that hypersensitivity to mosquito saliva influences blood feeding. To test this hypothesis, we recruited human subjects who consented to Aedes aegypti bites. We measured their first sensation of itch, the strength of their itch sensation, the number of times mosquitoes attempted to feed, the number of times mosquitoes probed their skin, feeding time, engorgement status, and wheal diameter. Here we show that hypersensitive subjects had a stronger itch sensation, and that the time to first itch sensation was inversely correlated with wheal diameter; however, mosquitoes tended to probe less and engorge more on these subjects. Follow-up experiments testing the impact of oral antihistamine treatment on mosquito feeding parameters failed to reveal a statistically significant result. Histamine also failed to promote blood feeding on an artificial membrane feeder. This study suggests that mosquito saliva-induced type I hypersensitivity promotes blood feeding but that this may be independent from histamine or histamine signaling.
format	article
author	Michael J. Conway
author_facet	Michael J. Conway
author_sort	Michael J. Conway
title	Type I hypersensitivity promotes Aedes aegypti blood feeding
title_short	Type I hypersensitivity promotes Aedes aegypti blood feeding
title_full	Type I hypersensitivity promotes Aedes aegypti blood feeding
title_fullStr	Type I hypersensitivity promotes Aedes aegypti blood feeding
title_full_unstemmed	Type I hypersensitivity promotes Aedes aegypti blood feeding
title_sort	type i hypersensitivity promotes aedes aegypti blood feeding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e82076ca08554391ad1f34a139e3bea5
work_keys_str_mv	AT michaeljconway typeihypersensitivitypromotesaedesaegyptibloodfeeding
_version_	1718384265576579072

Type I hypersensitivity promotes Aedes aegypti blood feeding

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