The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory,...
Guardado en:
Autores principales: | , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Dove Medical Press
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/e820b0a24c4a4ced9c5d44a571763878 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:e820b0a24c4a4ced9c5d44a571763878 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:e820b0a24c4a4ced9c5d44a5717638782021-12-02T07:50:28ZThe effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells1179-1314https://doaj.org/article/e820b0a24c4a4ced9c5d44a5717638782017-03-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-turmeric-curcumin-on-tumor-suppressor-protein-p53-and-e-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5–60 µM CUR. In cell proliferation studies, CUR alone caused a 10-fold decrease compared with the treatment with estrogen, which suggests its antiproliferative effects. Delineating the role of CUR in the regulation of p53, ERα, and their mechanisms of action may be important in understanding the influence of CUR on tumor suppressors and hormone receptors in breast cancer. Keywords: breast cancer, tumor suppressors, p53, estrogen, anti-estrogens, female sex steroids, turmericHallman KAleck KDwyer BLloyd VQuigley MSitto NSiebert AEDinda SDove Medical PressarticleBreast cancertumor suppressorsp53estrogenantiestrogensNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 153-161 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Breast cancer tumor suppressors p53 estrogen antiestrogens Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
Breast cancer tumor suppressors p53 estrogen antiestrogens Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hallman K Aleck K Dwyer B Lloyd V Quigley M Sitto N Siebert AE Dinda S The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
description |
Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5–60 µM CUR. In cell proliferation studies, CUR alone caused a 10-fold decrease compared with the treatment with estrogen, which suggests its antiproliferative effects. Delineating the role of CUR in the regulation of p53, ERα, and their mechanisms of action may be important in understanding the influence of CUR on tumor suppressors and hormone receptors in breast cancer. Keywords: breast cancer, tumor suppressors, p53, estrogen, anti-estrogens, female sex steroids, turmeric |
format |
article |
author |
Hallman K Aleck K Dwyer B Lloyd V Quigley M Sitto N Siebert AE Dinda S |
author_facet |
Hallman K Aleck K Dwyer B Lloyd V Quigley M Sitto N Siebert AE Dinda S |
author_sort |
Hallman K |
title |
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
title_short |
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
title_full |
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
title_fullStr |
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
title_full_unstemmed |
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells |
title_sort |
effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (erα) in breast cancer cells |
publisher |
Dove Medical Press |
publishDate |
2017 |
url |
https://doaj.org/article/e820b0a24c4a4ced9c5d44a571763878 |
work_keys_str_mv |
AT hallmank theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT aleckk theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT dwyerb theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT lloydv theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT quigleym theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT sitton theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT siebertae theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT dindas theeffectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT hallmank effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT aleckk effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT dwyerb effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT lloydv effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT quigleym effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT sitton effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT siebertae effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells AT dindas effectsofturmericcurcuminontumorsuppressorproteinp53andestrogenreceptoreralphainbreastcancercells |
_version_ |
1718399193551208448 |