The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells

Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory,...

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Autores principales: Hallman K, Aleck K, Dwyer B, Lloyd V, Quigley M, Sitto N, Siebert AE, Dinda S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
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Acceso en línea:https://doaj.org/article/e820b0a24c4a4ced9c5d44a571763878
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spelling oai:doaj.org-article:e820b0a24c4a4ced9c5d44a5717638782021-12-02T07:50:28ZThe effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells1179-1314https://doaj.org/article/e820b0a24c4a4ced9c5d44a5717638782017-03-01T00:00:00Zhttps://www.dovepress.com/the-effects-of-turmeric-curcumin-on-tumor-suppressor-protein-p53-and-e-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5–60 µM CUR. In cell proliferation studies, CUR alone caused a 10-fold decrease compared with the treatment with estrogen, which suggests its antiproliferative effects. Delineating the role of CUR in the regulation of p53, ERα, and their mechanisms of action may be important in understanding the influence of CUR on tumor suppressors and hormone receptors in breast cancer. Keywords: breast cancer, tumor suppressors, p53, estrogen, anti-estrogens, female sex steroids, turmericHallman KAleck KDwyer BLloyd VQuigley MSitto NSiebert AEDinda SDove Medical PressarticleBreast cancertumor suppressorsp53estrogenantiestrogensNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 9, Pp 153-161 (2017)
institution DOAJ
collection DOAJ
language EN
topic Breast cancer
tumor suppressors
p53
estrogen
antiestrogens
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
spellingShingle Breast cancer
tumor suppressors
p53
estrogen
antiestrogens
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Hallman K
Aleck K
Dwyer B
Lloyd V
Quigley M
Sitto N
Siebert AE
Dinda S
The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
description Kelly Hallman, Katie Aleck, Brigitte Dwyer, Victoria Lloyd, Meghan Quigley, Nada Sitto, Amy E Siebert, Sumi Dinda School of Health Sciences, Prevention Research Center, Oakland University, Rochester, MI, USA Abstract: Curcumin (CUR) is a compound that has antibacterial, antiviral, anti-inflammatory, and anticancer properties. In this study, we have analyzed the effects of CUR on the expression of ERα and p53 in the presence of hormones and anti-hormones in breast cancer cells. Cells were cultured in a medium containing charcoal-stripped fetal bovine serum to deplete any endogenous steroids and treated with CUR at varying concentrations or in combination with hormones and anti-hormones. Protein analysis revealed a relative decrease in the levels of p53 and ERα upon treatment with 5–60 µM CUR. In cell proliferation studies, CUR alone caused a 10-fold decrease compared with the treatment with estrogen, which suggests its antiproliferative effects. Delineating the role of CUR in the regulation of p53, ERα, and their mechanisms of action may be important in understanding the influence of CUR on tumor suppressors and hormone receptors in breast cancer. Keywords: breast cancer, tumor suppressors, p53, estrogen, anti-estrogens, female sex steroids, turmeric
format article
author Hallman K
Aleck K
Dwyer B
Lloyd V
Quigley M
Sitto N
Siebert AE
Dinda S
author_facet Hallman K
Aleck K
Dwyer B
Lloyd V
Quigley M
Sitto N
Siebert AE
Dinda S
author_sort Hallman K
title The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
title_short The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
title_full The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
title_fullStr The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
title_full_unstemmed The effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (ERα) in breast cancer cells
title_sort effects of turmeric (curcumin) on tumor suppressor protein (p53) and estrogen receptor (erα) in breast cancer cells
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/e820b0a24c4a4ced9c5d44a571763878
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