Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria
Abstract After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected menin...
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2018
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oai:doaj.org-article:e8222612809e4b29b4b6336e4ca00f7d2021-12-02T15:08:16ZMeningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria10.1038/s41598-018-32475-22045-2322https://doaj.org/article/e8222612809e4b29b4b6336e4ca00f7d2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32475-2https://doaj.org/toc/2045-2322Abstract After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.Brenda A. Kwambana-AdamsRahab C. AmazaCatherine OkoiMurtala RabiuArchibald WorwuiEbenezer Foster-NyarkoBernard EbrukeAbdul K. SesayMadikay SenghoreAbdullahi S. UmarRabi UsmanAdamu AtikuGarba AbdullahiYahaya BuhariRabiu SaniHusaini U. BakoBashir AbdullahiAlliyu I. YarimaBadaru SikiruAderinola Olaolu MosesMichael O. PopoolaEme EkengAdebola OlayinkaNwando MbaAdamu KankiaIbrahim N. MamaduIfeanyi OkudoMary StephenOlivier RonveauxJason BusuttilJason M. MwendaMohammed AbdulazizSulaiman A. GummiAdebayo AdedejiAndre BitaLinda OmarMamoudou Harouna DjingareyWondimagegnehu AlemuUmberto D’AlessandroChikwe IhekweazuMartin AntonioNature PortfolioarticleZamfara StateMeningococcal SerogroupSuspected Meningitis CasesMeningitis OutbreakMenAfriVacMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
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Zamfara State Meningococcal Serogroup Suspected Meningitis Cases Meningitis Outbreak MenAfriVac Medicine R Science Q |
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Zamfara State Meningococcal Serogroup Suspected Meningitis Cases Meningitis Outbreak MenAfriVac Medicine R Science Q Brenda A. Kwambana-Adams Rahab C. Amaza Catherine Okoi Murtala Rabiu Archibald Worwui Ebenezer Foster-Nyarko Bernard Ebruke Abdul K. Sesay Madikay Senghore Abdullahi S. Umar Rabi Usman Adamu Atiku Garba Abdullahi Yahaya Buhari Rabiu Sani Husaini U. Bako Bashir Abdullahi Alliyu I. Yarima Badaru Sikiru Aderinola Olaolu Moses Michael O. Popoola Eme Ekeng Adebola Olayinka Nwando Mba Adamu Kankia Ibrahim N. Mamadu Ifeanyi Okudo Mary Stephen Olivier Ronveaux Jason Busuttil Jason M. Mwenda Mohammed Abdulaziz Sulaiman A. Gummi Adebayo Adedeji Andre Bita Linda Omar Mamoudou Harouna Djingarey Wondimagegnehu Alemu Umberto D’Alessandro Chikwe Ihekweazu Martin Antonio Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| description |
Abstract After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5–14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5–9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks. |
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| author |
Brenda A. Kwambana-Adams Rahab C. Amaza Catherine Okoi Murtala Rabiu Archibald Worwui Ebenezer Foster-Nyarko Bernard Ebruke Abdul K. Sesay Madikay Senghore Abdullahi S. Umar Rabi Usman Adamu Atiku Garba Abdullahi Yahaya Buhari Rabiu Sani Husaini U. Bako Bashir Abdullahi Alliyu I. Yarima Badaru Sikiru Aderinola Olaolu Moses Michael O. Popoola Eme Ekeng Adebola Olayinka Nwando Mba Adamu Kankia Ibrahim N. Mamadu Ifeanyi Okudo Mary Stephen Olivier Ronveaux Jason Busuttil Jason M. Mwenda Mohammed Abdulaziz Sulaiman A. Gummi Adebayo Adedeji Andre Bita Linda Omar Mamoudou Harouna Djingarey Wondimagegnehu Alemu Umberto D’Alessandro Chikwe Ihekweazu Martin Antonio |
| author_facet |
Brenda A. Kwambana-Adams Rahab C. Amaza Catherine Okoi Murtala Rabiu Archibald Worwui Ebenezer Foster-Nyarko Bernard Ebruke Abdul K. Sesay Madikay Senghore Abdullahi S. Umar Rabi Usman Adamu Atiku Garba Abdullahi Yahaya Buhari Rabiu Sani Husaini U. Bako Bashir Abdullahi Alliyu I. Yarima Badaru Sikiru Aderinola Olaolu Moses Michael O. Popoola Eme Ekeng Adebola Olayinka Nwando Mba Adamu Kankia Ibrahim N. Mamadu Ifeanyi Okudo Mary Stephen Olivier Ronveaux Jason Busuttil Jason M. Mwenda Mohammed Abdulaziz Sulaiman A. Gummi Adebayo Adedeji Andre Bita Linda Omar Mamoudou Harouna Djingarey Wondimagegnehu Alemu Umberto D’Alessandro Chikwe Ihekweazu Martin Antonio |
| author_sort |
Brenda A. Kwambana-Adams |
| title |
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| title_short |
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| title_full |
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| title_fullStr |
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| title_full_unstemmed |
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria |
| title_sort |
meningococcus serogroup c clonal complex st-10217 outbreak in zamfara state, northern nigeria |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/e8222612809e4b29b4b6336e4ca00f7d |
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