Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Intervertebral disc degeneration is a leading cause of chronic back pain and disability. Here the authors show that long term treatment with senolytic compounds Dasatinib and Quercetin reduces disc senescence burden and ameliorates age-dependent degeneration in mice.

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Autores principales:	Emanuel J. Novais, Victoria A. Tran, Shira N. Johnston, Kayla R. Darris, Alex J. Roupas, Garrett A. Sessions, Irving M. Shapiro, Brian O. Diekman, Makarand V. Risbud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e824b98a87ac47fa8c57f62f8e079e2c
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spelling	oai:doaj.org-article:e824b98a87ac47fa8c57f62f8e079e2c2021-12-02T16:38:26ZLong-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice10.1038/s41467-021-25453-22041-1723https://doaj.org/article/e824b98a87ac47fa8c57f62f8e079e2c2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25453-2https://doaj.org/toc/2041-1723Intervertebral disc degeneration is a leading cause of chronic back pain and disability. Here the authors show that long term treatment with senolytic compounds Dasatinib and Quercetin reduces disc senescence burden and ameliorates age-dependent degeneration in mice.Emanuel J. NovaisVictoria A. TranShira N. JohnstonKayla R. DarrisAlex J. RoupasGarrett A. SessionsIrving M. ShapiroBrian O. DiekmanMakarand V. RisbudNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emanuel J. Novais Victoria A. Tran Shira N. Johnston Kayla R. Darris Alex J. Roupas Garrett A. Sessions Irving M. Shapiro Brian O. Diekman Makarand V. Risbud Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
description	Intervertebral disc degeneration is a leading cause of chronic back pain and disability. Here the authors show that long term treatment with senolytic compounds Dasatinib and Quercetin reduces disc senescence burden and ameliorates age-dependent degeneration in mice.
format	article
author	Emanuel J. Novais Victoria A. Tran Shira N. Johnston Kayla R. Darris Alex J. Roupas Garrett A. Sessions Irving M. Shapiro Brian O. Diekman Makarand V. Risbud
author_facet	Emanuel J. Novais Victoria A. Tran Shira N. Johnston Kayla R. Darris Alex J. Roupas Garrett A. Sessions Irving M. Shapiro Brian O. Diekman Makarand V. Risbud
author_sort	Emanuel J. Novais
title	Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
title_short	Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
title_full	Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
title_fullStr	Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
title_full_unstemmed	Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice
title_sort	long-term treatment with senolytic drugs dasatinib and quercetin ameliorates age-dependent intervertebral disc degeneration in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e824b98a87ac47fa8c57f62f8e079e2c
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Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

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