Lipid Interactions Between Flaviviruses and Mosquito Vectors

Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requir...

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Autores principales:	Thomas Vial, Guillaume Marti, Dorothée Missé, Julien Pompon
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	mosquito flavivirus phospholipids transmission metabolomics Physiology QP1-981
Acceso en línea:	https://doaj.org/article/e824cbe559f748899fcbf69565355dec
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spelling	oai:doaj.org-article:e824cbe559f748899fcbf69565355dec2021-11-09T17:28:55ZLipid Interactions Between Flaviviruses and Mosquito Vectors1664-042X10.3389/fphys.2021.763195https://doaj.org/article/e824cbe559f748899fcbf69565355dec2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.763195/fullhttps://doaj.org/toc/1664-042XMosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.Thomas VialThomas VialGuillaume MartiGuillaume MartiDorothée MisséJulien PomponFrontiers Media S.A.articlemosquitoflavivirusphospholipidstransmissionmetabolomicsPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mosquito flavivirus phospholipids transmission metabolomics Physiology QP1-981
spellingShingle	mosquito flavivirus phospholipids transmission metabolomics Physiology QP1-981 Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon Lipid Interactions Between Flaviviruses and Mosquito Vectors
description	Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.
format	article
author	Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon
author_facet	Thomas Vial Thomas Vial Guillaume Marti Guillaume Marti Dorothée Missé Julien Pompon
author_sort	Thomas Vial
title	Lipid Interactions Between Flaviviruses and Mosquito Vectors
title_short	Lipid Interactions Between Flaviviruses and Mosquito Vectors
title_full	Lipid Interactions Between Flaviviruses and Mosquito Vectors
title_fullStr	Lipid Interactions Between Flaviviruses and Mosquito Vectors
title_full_unstemmed	Lipid Interactions Between Flaviviruses and Mosquito Vectors
title_sort	lipid interactions between flaviviruses and mosquito vectors
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e824cbe559f748899fcbf69565355dec
work_keys_str_mv	AT thomasvial lipidinteractionsbetweenflavivirusesandmosquitovectors AT thomasvial lipidinteractionsbetweenflavivirusesandmosquitovectors AT guillaumemarti lipidinteractionsbetweenflavivirusesandmosquitovectors AT guillaumemarti lipidinteractionsbetweenflavivirusesandmosquitovectors AT dorotheemisse lipidinteractionsbetweenflavivirusesandmosquitovectors AT julienpompon lipidinteractionsbetweenflavivirusesandmosquitovectors
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Lipid Interactions Between Flaviviruses and Mosquito Vectors

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