The composition of lung microbiome in lung cancer: a systematic review and meta-analysis

Abstract Background Although recent studies have indicated that imbalance in the respiratory microbiome composition is linked to several chronic respiratory diseases, the association between the lung microbiome and lung cancer has not been extensively studied. Conflicting reports of individual studi...

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Autores principales:	Sadaf Najafi, Fatemeh Abedini, Sadegh Azimzadeh Jamalkandi, Parvin Shariati, Ali Ahmadi, Mohammad Gholami Fesharaki
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Lung microbiome Lung cancer Meta-analysis 16S rRNA gene Metagenomics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e827026e8ef9491da88290d3636efca6
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spelling	oai:doaj.org-article:e827026e8ef9491da88290d3636efca62021-11-14T12:08:52ZThe composition of lung microbiome in lung cancer: a systematic review and meta-analysis10.1186/s12866-021-02375-z1471-2180https://doaj.org/article/e827026e8ef9491da88290d3636efca62021-11-01T00:00:00Zhttps://doi.org/10.1186/s12866-021-02375-zhttps://doaj.org/toc/1471-2180Abstract Background Although recent studies have indicated that imbalance in the respiratory microbiome composition is linked to several chronic respiratory diseases, the association between the lung microbiome and lung cancer has not been extensively studied. Conflicting reports of individual studies on respiratory microbiome alterations in lung cancer complicate the matter for specifying how the lung microbiome is linked to lung cancer. Consequently, as the first meta-analysis on this topic, we integrate publicly available 16S rRNA gene sequence data on lung tissue samples of lung cancer patients to identify bacterial taxa which differ consistently between case and control groups. Results The findings of the current study suggest that the relative abundance of several bacterial taxa including Actinobacteria phylum, Corynebacteriaceae and Halomonadaceae families, and Corynebacterium, Lachnoanaerobaculum, and Halomonas genera is significantly decreased (p < 0.05) in lung tumor tissues of lung cancer patients in comparison with tumor-adjacent normal tissues. Conclusions Despite the underlying need for scrutinizing the findings further, the present study lays the groundwork for future research and adds to our limited understanding of the key role of the lung microbiome and its complex interaction with lung cancer. More data on demographic factors and tumor tissue types would help establish a greater degree of accuracy in characterizing the lung microbial community which accords with subtypes and stages of the disease and fully capturing the changes of the lung microbiome in lung cancer.Sadaf NajafiFatemeh AbediniSadegh Azimzadeh JamalkandiParvin ShariatiAli AhmadiMohammad Gholami FesharakiBMCarticleLung microbiomeLung cancerMeta-analysis16S rRNA geneMetagenomicsMicrobiologyQR1-502ENBMC Microbiology, Vol 21, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lung microbiome Lung cancer Meta-analysis 16S rRNA gene Metagenomics Microbiology QR1-502
spellingShingle	Lung microbiome Lung cancer Meta-analysis 16S rRNA gene Metagenomics Microbiology QR1-502 Sadaf Najafi Fatemeh Abedini Sadegh Azimzadeh Jamalkandi Parvin Shariati Ali Ahmadi Mohammad Gholami Fesharaki The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
description	Abstract Background Although recent studies have indicated that imbalance in the respiratory microbiome composition is linked to several chronic respiratory diseases, the association between the lung microbiome and lung cancer has not been extensively studied. Conflicting reports of individual studies on respiratory microbiome alterations in lung cancer complicate the matter for specifying how the lung microbiome is linked to lung cancer. Consequently, as the first meta-analysis on this topic, we integrate publicly available 16S rRNA gene sequence data on lung tissue samples of lung cancer patients to identify bacterial taxa which differ consistently between case and control groups. Results The findings of the current study suggest that the relative abundance of several bacterial taxa including Actinobacteria phylum, Corynebacteriaceae and Halomonadaceae families, and Corynebacterium, Lachnoanaerobaculum, and Halomonas genera is significantly decreased (p < 0.05) in lung tumor tissues of lung cancer patients in comparison with tumor-adjacent normal tissues. Conclusions Despite the underlying need for scrutinizing the findings further, the present study lays the groundwork for future research and adds to our limited understanding of the key role of the lung microbiome and its complex interaction with lung cancer. More data on demographic factors and tumor tissue types would help establish a greater degree of accuracy in characterizing the lung microbial community which accords with subtypes and stages of the disease and fully capturing the changes of the lung microbiome in lung cancer.
format	article
author	Sadaf Najafi Fatemeh Abedini Sadegh Azimzadeh Jamalkandi Parvin Shariati Ali Ahmadi Mohammad Gholami Fesharaki
author_facet	Sadaf Najafi Fatemeh Abedini Sadegh Azimzadeh Jamalkandi Parvin Shariati Ali Ahmadi Mohammad Gholami Fesharaki
author_sort	Sadaf Najafi
title	The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
title_short	The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
title_full	The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
title_fullStr	The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
title_full_unstemmed	The composition of lung microbiome in lung cancer: a systematic review and meta-analysis
title_sort	composition of lung microbiome in lung cancer: a systematic review and meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e827026e8ef9491da88290d3636efca6
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The composition of lung microbiome in lung cancer: a systematic review and meta-analysis

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