Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia

Gizachew Ayele Manaye,1 Dejene Derseh Abateneh,2 Wondwossen Niguse3 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Teferi, Ethiopia; 2Department of Medical Laboratory Science, Menelik II College of Medicine and Health Sciences, Kotebe...

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Autores principales:	Manaye GA, Abateneh DD, Niguse W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	chronic kidney disease hiv/aids haart ethiopia Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e827ec790d034889a5c371321f8062f8
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spelling	oai:doaj.org-article:e827ec790d034889a5c371321f8062f82021-12-02T10:19:23ZChronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia1179-1373https://doaj.org/article/e827ec790d034889a5c371321f8062f82020-10-01T00:00:00Zhttps://www.dovepress.com/chronic-kidney-disease-and-associated-factors-among-hivaids-patients-o-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Gizachew Ayele Manaye,1 Dejene Derseh Abateneh,2 Wondwossen Niguse3 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Teferi, Ethiopia; 2Department of Medical Laboratory Science, Menelik II College of Medicine and Health Sciences, Kotebe Metropolitan University, Addis Ababa, Ethiopia; 3Department of Nursing, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Teferi, EthiopiaCorrespondence: Gizachew Ayele ManayeDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, P.O. Box: 206, Mizan Tefri, EthiopiaTel +251928444333Email ayele.gizachew@yahoo.comBackground: In developing countries, both opportunistic infections and chronic diseases account a high HIV-associated mortality and morbidity. Chronic kidney disease (CKD) associated with HIV infection has got increased attention in sub-Saharan Africa as a result of the high HIV prevalence and due to the late diagnosis and initiation of HAART. Thus, this study was conducted to assess CKD and associated factors among HIV patients on HAART in Ethiopia.Methods: A hospital-based cross-sectional study with a secondary data review was conducted on 336 on HIV/AIDS patients on HAART from February to July 2017 at University of Gondar Referral Hospital. The study participants were selected using a systematic random sampling technique. Socio-demographic and clinical data were collected using a semi-structured questionnaire at their follow-up date with interview and chart review. Three to five milliliters of venous blood and five milliliters of urine specimen were collected for serum creatinine and urine albumin determination, respectively. Data were entered into SPSS version 20 for analysis. Glomerular filtration rate was estimated using the CKD-EPI estimator. Bivariate and multivariate logistic regression was employed and p-value < 0.2 and < 0.05, respectively, was considered statistically significant.Results: The prevalence of CKD on the study participants was 54 (16.1%) (95% CI, 12.2– 20.4%). By stage, about 27 (8.0%) had stage 1 (persistent proteinuria with eGFR ≥ 90 mL/min/1.73 m2), 16 (4.8%) had stage 2 (persistent proteinuria with eGFR of 60– 89.9 mL/min/1.73 m2), 6 (1.8%) had stage 3 (eGFR 30– 59.9 mL/min/1.73 m2 with or without proteinuria) and 5 (1.5%) had stage 5 ((kidney failure), eGFR< 15mL/min/1.73 m2 with or without proteinuria). With multivariate logistic regression analysis, being male (AOR=2.05 (1.03– 4.09), p=0.04), being merchant (AOR=2.91 (1.00– 8.48), p=0.049) and having viral load≥ 1000 copies/mm3 (AOR=3.1 (1.38– 7.00), P< 0.01) were significantly associated with CKD.Conclusion: The prevalence of CKD among HIV patients on HARRT is high. Being male, merchant and having viral load ≥ 1000 copies/mm3 were associated factors of CKD. Patients should be regularly monitored and screened for early diagnosis and management of CKD. Those patients who have being merchant with high viral load and male patients should require close monitoring.Keywords: chronic kidney disease, HIV/AIDS, HAART, EthiopiaManaye GAAbateneh DDNiguse WDove Medical Pressarticlechronic kidney diseasehiv/aidshaartethiopiaImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 591-599 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease hiv/aids haart ethiopia Immunologic diseases. Allergy RC581-607
spellingShingle	chronic kidney disease hiv/aids haart ethiopia Immunologic diseases. Allergy RC581-607 Manaye GA Abateneh DD Niguse W Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
description	Gizachew Ayele Manaye,1 Dejene Derseh Abateneh,2 Wondwossen Niguse3 1Department of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Teferi, Ethiopia; 2Department of Medical Laboratory Science, Menelik II College of Medicine and Health Sciences, Kotebe Metropolitan University, Addis Ababa, Ethiopia; 3Department of Nursing, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan Teferi, EthiopiaCorrespondence: Gizachew Ayele ManayeDepartment of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, P.O. Box: 206, Mizan Tefri, EthiopiaTel +251928444333Email ayele.gizachew@yahoo.comBackground: In developing countries, both opportunistic infections and chronic diseases account a high HIV-associated mortality and morbidity. Chronic kidney disease (CKD) associated with HIV infection has got increased attention in sub-Saharan Africa as a result of the high HIV prevalence and due to the late diagnosis and initiation of HAART. Thus, this study was conducted to assess CKD and associated factors among HIV patients on HAART in Ethiopia.Methods: A hospital-based cross-sectional study with a secondary data review was conducted on 336 on HIV/AIDS patients on HAART from February to July 2017 at University of Gondar Referral Hospital. The study participants were selected using a systematic random sampling technique. Socio-demographic and clinical data were collected using a semi-structured questionnaire at their follow-up date with interview and chart review. Three to five milliliters of venous blood and five milliliters of urine specimen were collected for serum creatinine and urine albumin determination, respectively. Data were entered into SPSS version 20 for analysis. Glomerular filtration rate was estimated using the CKD-EPI estimator. Bivariate and multivariate logistic regression was employed and p-value < 0.2 and < 0.05, respectively, was considered statistically significant.Results: The prevalence of CKD on the study participants was 54 (16.1%) (95% CI, 12.2– 20.4%). By stage, about 27 (8.0%) had stage 1 (persistent proteinuria with eGFR ≥ 90 mL/min/1.73 m2), 16 (4.8%) had stage 2 (persistent proteinuria with eGFR of 60– 89.9 mL/min/1.73 m2), 6 (1.8%) had stage 3 (eGFR 30– 59.9 mL/min/1.73 m2 with or without proteinuria) and 5 (1.5%) had stage 5 ((kidney failure), eGFR< 15mL/min/1.73 m2 with or without proteinuria). With multivariate logistic regression analysis, being male (AOR=2.05 (1.03– 4.09), p=0.04), being merchant (AOR=2.91 (1.00– 8.48), p=0.049) and having viral load≥ 1000 copies/mm3 (AOR=3.1 (1.38– 7.00), P< 0.01) were significantly associated with CKD.Conclusion: The prevalence of CKD among HIV patients on HARRT is high. Being male, merchant and having viral load ≥ 1000 copies/mm3 were associated factors of CKD. Patients should be regularly monitored and screened for early diagnosis and management of CKD. Those patients who have being merchant with high viral load and male patients should require close monitoring.Keywords: chronic kidney disease, HIV/AIDS, HAART, Ethiopia
format	article
author	Manaye GA Abateneh DD Niguse W
author_facet	Manaye GA Abateneh DD Niguse W
author_sort	Manaye GA
title	Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
title_short	Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
title_full	Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
title_fullStr	Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
title_full_unstemmed	Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia
title_sort	chronic kidney disease and associated factors among hiv/aids patients on haart in ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/e827ec790d034889a5c371321f8062f8
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Chronic Kidney Disease and Associated Factors Among HIV/AIDS Patients on HAART in Ethiopia

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