Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis

Abstract The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and aspartate a...

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Autores principales:	Xiankui Li, Lei Wang, Cai Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e82c44a74a0049cb838c03ee0a6d1d14
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spelling	oai:doaj.org-article:e82c44a74a0049cb838c03ee0a6d1d142021-12-02T11:40:45ZEffects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis10.1038/s41598-017-06318-52045-2322https://doaj.org/article/e82c44a74a0049cb838c03ee0a6d1d142017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06318-5https://doaj.org/toc/2045-2322Abstract The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and aspartate aminotransferase, hepatic malondialdehyde formation, decreases in antioxidants including superoxide dismutase and glutathione, and up-regulated expressions of transforming growth factor-β1, α-smooth muscle actin, tumor necrosis factor-α and interleukin-1β in the liver tissues. Hydroxyproline contents in the rat livers were increased by CCl4. Histopathological examinations indicated that CCl4 induced extensive necrosis in mice livers and pseudo-lobule formations, collagen deposition in rats livers. However, all these changes in mice and rats were significantly attenuated by exogenous TB4 treatment. Furthermore, up-regulations of nuclear factor-κB p65 protein expression by CCl4 treatment in mice and rats livers were also remarkably reduced by exogenous TB4 administration. Taken together, findings in this study suggested that exogenous TB4 might prevent CCl4-induced acute liver injury and subsequent fibrosis through alleviating oxidative stress and inflammation.Xiankui LiLei WangCai ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiankui Li Lei Wang Cai Chen Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
description	Abstract The present study investigated the effects of exogenous thymosin β4 (TB4) on carbon tetrachloride (CCl4)-induced acute liver injury and fibrosis in rodent animals. Results showed that both in mice and rats CCl4 rendered significant increases in serum alanine aminotransferase and aspartate aminotransferase, hepatic malondialdehyde formation, decreases in antioxidants including superoxide dismutase and glutathione, and up-regulated expressions of transforming growth factor-β1, α-smooth muscle actin, tumor necrosis factor-α and interleukin-1β in the liver tissues. Hydroxyproline contents in the rat livers were increased by CCl4. Histopathological examinations indicated that CCl4 induced extensive necrosis in mice livers and pseudo-lobule formations, collagen deposition in rats livers. However, all these changes in mice and rats were significantly attenuated by exogenous TB4 treatment. Furthermore, up-regulations of nuclear factor-κB p65 protein expression by CCl4 treatment in mice and rats livers were also remarkably reduced by exogenous TB4 administration. Taken together, findings in this study suggested that exogenous TB4 might prevent CCl4-induced acute liver injury and subsequent fibrosis through alleviating oxidative stress and inflammation.
format	article
author	Xiankui Li Lei Wang Cai Chen
author_facet	Xiankui Li Lei Wang Cai Chen
author_sort	Xiankui Li
title	Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
title_short	Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
title_full	Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
title_fullStr	Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
title_full_unstemmed	Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
title_sort	effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e82c44a74a0049cb838c03ee0a6d1d14
work_keys_str_mv	AT xiankuili effectsofexogenousthymosinb4oncarbontetrachlorideinducedliverinjuryandfibrosis AT leiwang effectsofexogenousthymosinb4oncarbontetrachlorideinducedliverinjuryandfibrosis AT caichen effectsofexogenousthymosinb4oncarbontetrachlorideinducedliverinjuryandfibrosis
_version_	1718395555340615680

Effects of exogenous thymosin β4 on carbon tetrachloride-induced liver injury and fibrosis

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