Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT

Nauman Hashmani, Sharif Hashmani, Asif Murad, Sayed Mustafa Mahmood Shah, Maria Hashmani Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan Purpose: To quantify and view the possible influence of demographic variables on normal macular layers. Additionally, we w...

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Autores principales:	Hashmani N, Hashmani S, Murad A, Mahmood Shah SM, Hashmani M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Optical coherence tomography OCT Macula Retina Normality Reproducibility Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/e82c6fe74a0749b49b0126c5f308704b
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spelling	oai:doaj.org-article:e82c6fe74a0749b49b0126c5f308704b2021-12-02T05:16:25ZAssessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT1177-5483https://doaj.org/article/e82c6fe74a0749b49b0126c5f308704b2018-08-01T00:00:00Zhttps://www.dovepress.com/assessing-reproducibility-and-the-effects-of-demographic-variables-on--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Nauman Hashmani, Sharif Hashmani, Asif Murad, Sayed Mustafa Mahmood Shah, Maria Hashmani Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan Purpose: To quantify and view the possible influence of demographic variables on normal macular layers. Additionally, we wanted to assess the reproducibility using the Spectralis SD-OCT. Methods: A Spectralis SD-OCT machine using a commercially available algorithm was used to scan 242 healthy subjects in an outpatient setting. We examined retinal thicknesses in seven layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) and retinal pigment epithelium (RPE). Combined retinal thicknesses were expressed as inner retinal layer (IRL), photoreceptor layer (PL) and total retinal thickness (TRT). Measurements were taken from each of the nine sectors defined by the Early Treatment Diabetic Retinopathy Study; the center was the fovea, the inner circle (IC) was 1–3 mm away, and the outer circle (OC) was 3–6 mm away. Results: The TRT was thickest inferiorly in the IC, and superiorly in the OC. The RNFL (P=0.030), GCL (P=0.006), IPL (P=0.006), IRL (P=0.030), PL (P<0.001) and TRT (P=0.001) were found to be thicker in males. The GCL (r=0.078, P=0.001), IPL (r=0.079, P=0.001), IRL (r=0.072, P=0.002), PL (r=0.076, P=0.001) and TRT (r=0.090, P<0.001) were found to decrease with age. The INL (r=0.060, P=0.010), ONL (r=0.078, P=0.001), and RPE (r=0.066, P=0.004) were inversely related to axial length. Excellent reproducibility was observed in all layers. Conclusion: Our study shows differences in various retinal layers according to age, gender, and axial length. Additionally, we demonstrate excellent reproducibility of this algorithm using the Spectralis SD-OCT. Keywords: macular mapping, retinal layers, retinal mappingHashmani NHashmani SMurad AMahmood Shah SMHashmani MDove Medical PressarticleOptical coherence tomographyOCTMaculaRetinaNormalityReproducibilityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 1433-1440 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Optical coherence tomography OCT Macula Retina Normality Reproducibility Ophthalmology RE1-994
spellingShingle	Optical coherence tomography OCT Macula Retina Normality Reproducibility Ophthalmology RE1-994 Hashmani N Hashmani S Murad A Mahmood Shah SM Hashmani M Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
description	Nauman Hashmani, Sharif Hashmani, Asif Murad, Sayed Mustafa Mahmood Shah, Maria Hashmani Department of Ophthalmology and Visual Sciences, Hashmanis Hospital, Karachi, Pakistan Purpose: To quantify and view the possible influence of demographic variables on normal macular layers. Additionally, we wanted to assess the reproducibility using the Spectralis SD-OCT. Methods: A Spectralis SD-OCT machine using a commercially available algorithm was used to scan 242 healthy subjects in an outpatient setting. We examined retinal thicknesses in seven layers: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL) and retinal pigment epithelium (RPE). Combined retinal thicknesses were expressed as inner retinal layer (IRL), photoreceptor layer (PL) and total retinal thickness (TRT). Measurements were taken from each of the nine sectors defined by the Early Treatment Diabetic Retinopathy Study; the center was the fovea, the inner circle (IC) was 1–3 mm away, and the outer circle (OC) was 3–6 mm away. Results: The TRT was thickest inferiorly in the IC, and superiorly in the OC. The RNFL (P=0.030), GCL (P=0.006), IPL (P=0.006), IRL (P=0.030), PL (P<0.001) and TRT (P=0.001) were found to be thicker in males. The GCL (r=0.078, P=0.001), IPL (r=0.079, P=0.001), IRL (r=0.072, P=0.002), PL (r=0.076, P=0.001) and TRT (r=0.090, P<0.001) were found to decrease with age. The INL (r=0.060, P=0.010), ONL (r=0.078, P=0.001), and RPE (r=0.066, P=0.004) were inversely related to axial length. Excellent reproducibility was observed in all layers. Conclusion: Our study shows differences in various retinal layers according to age, gender, and axial length. Additionally, we demonstrate excellent reproducibility of this algorithm using the Spectralis SD-OCT. Keywords: macular mapping, retinal layers, retinal mapping
format	article
author	Hashmani N Hashmani S Murad A Mahmood Shah SM Hashmani M
author_facet	Hashmani N Hashmani S Murad A Mahmood Shah SM Hashmani M
author_sort	Hashmani N
title	Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
title_short	Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
title_full	Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
title_fullStr	Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
title_full_unstemmed	Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
title_sort	assessing reproducibility and the effects of demographic variables on the normal macular layers using the spectralis sd-oct
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/e82c6fe74a0749b49b0126c5f308704b
work_keys_str_mv	AT hashmanin assessingreproducibilityandtheeffectsofdemographicvariablesonthenormalmacularlayersusingthespectralissdoct AT hashmanis assessingreproducibilityandtheeffectsofdemographicvariablesonthenormalmacularlayersusingthespectralissdoct AT murada assessingreproducibilityandtheeffectsofdemographicvariablesonthenormalmacularlayersusingthespectralissdoct AT mahmoodshahsm assessingreproducibilityandtheeffectsofdemographicvariablesonthenormalmacularlayersusingthespectralissdoct AT hashmanim assessingreproducibilityandtheeffectsofdemographicvariablesonthenormalmacularlayersusingthespectralissdoct
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Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT

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