The molecular basis of JAK/STAT inhibition by SOCS1

Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOC...

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Autores principales:	Nicholas P. D. Liau, Artem Laktyushin, Isabelle S. Lucet, James M. Murphy, Shenggen Yao, Eden Whitlock, Kimberley Callaghan, Nicos A. Nicola, Nadia J. Kershaw, Jeffrey J. Babon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e82cd8b59644469288505cb69474018c
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spelling	oai:doaj.org-article:e82cd8b59644469288505cb69474018c2021-12-02T17:32:03ZThe molecular basis of JAK/STAT inhibition by SOCS110.1038/s41467-018-04013-12041-1723https://doaj.org/article/e82cd8b59644469288505cb69474018c2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04013-1https://doaj.org/toc/2041-1723Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.Nicholas P. D. LiauArtem LaktyushinIsabelle S. LucetJames M. MurphyShenggen YaoEden WhitlockKimberley CallaghanNicos A. NicolaNadia J. KershawJeffrey J. BabonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas P. D. Liau Artem Laktyushin Isabelle S. Lucet James M. Murphy Shenggen Yao Eden Whitlock Kimberley Callaghan Nicos A. Nicola Nadia J. Kershaw Jeffrey J. Babon The molecular basis of JAK/STAT inhibition by SOCS1
description	Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOCS1.
format	article
author	Nicholas P. D. Liau Artem Laktyushin Isabelle S. Lucet James M. Murphy Shenggen Yao Eden Whitlock Kimberley Callaghan Nicos A. Nicola Nadia J. Kershaw Jeffrey J. Babon
author_facet	Nicholas P. D. Liau Artem Laktyushin Isabelle S. Lucet James M. Murphy Shenggen Yao Eden Whitlock Kimberley Callaghan Nicos A. Nicola Nadia J. Kershaw Jeffrey J. Babon
author_sort	Nicholas P. D. Liau
title	The molecular basis of JAK/STAT inhibition by SOCS1
title_short	The molecular basis of JAK/STAT inhibition by SOCS1
title_full	The molecular basis of JAK/STAT inhibition by SOCS1
title_fullStr	The molecular basis of JAK/STAT inhibition by SOCS1
title_full_unstemmed	The molecular basis of JAK/STAT inhibition by SOCS1
title_sort	molecular basis of jak/stat inhibition by socs1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e82cd8b59644469288505cb69474018c
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The molecular basis of JAK/STAT inhibition by SOCS1

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