Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis

ABSTRACT Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their ef...

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Autores principales:	Rosana Alves, Maria Sousa-Silva, Daniel Vieira, Pedro Soares, Yasmin Chebaro, Michael C. Lorenz, Margarida Casal, Isabel Soares-Silva, Sandra Paiva
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	Candida species acetate candidiasis carboxylate transporters lactate Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/e82f3331b61542e7a4fca764a74179c1
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spelling	oai:doaj.org-article:e82f3331b61542e7a4fca764a74179c12021-11-15T15:56:47ZCarboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis10.1128/mBio.00156-202150-7511https://doaj.org/article/e82f3331b61542e7a4fca764a74179c12020-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00156-20https://doaj.org/toc/2150-7511ABSTRACT Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated plasma membrane transporters plays a critical role in such nutrient-limited conditions. Here, we cover the physiology and regulation of these proteins and their potential role in Candida virulence. This review also presents an evolutionary analysis of orthologues of the Saccharomyces cerevisiae Jen1 lactate and Ady2 acetate transporters, including a phylogenetic analysis of 101 putative carboxylate transporters in twelve medically relevant Candida species. These proteins are assigned to distinct clades according to their amino acid sequence homology and represent the major carboxylic acid uptake systems in yeast. While Jen transporters belong to the sialate:H+ symporter (SHS) family, the Ady2 homologue members are assigned to the acetate uptake transporter (AceTr) family. Here, we reclassify the later members as ATO (acetate transporter ortholog). The new nomenclature will facilitate the study of these transporters, as well as the analysis of their relevance for Candida pathogenesis.Rosana AlvesMaria Sousa-SilvaDaniel VieiraPedro SoaresYasmin ChebaroMichael C. LorenzMargarida CasalIsabel Soares-SilvaSandra PaivaAmerican Society for MicrobiologyarticleCandida speciesacetatecandidiasiscarboxylate transporterslactateMicrobiologyQR1-502ENmBio, Vol 11, Iss 3 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida species acetate candidiasis carboxylate transporters lactate Microbiology QR1-502
spellingShingle	Candida species acetate candidiasis carboxylate transporters lactate Microbiology QR1-502 Rosana Alves Maria Sousa-Silva Daniel Vieira Pedro Soares Yasmin Chebaro Michael C. Lorenz Margarida Casal Isabel Soares-Silva Sandra Paiva Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
description	ABSTRACT Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated plasma membrane transporters plays a critical role in such nutrient-limited conditions. Here, we cover the physiology and regulation of these proteins and their potential role in Candida virulence. This review also presents an evolutionary analysis of orthologues of the Saccharomyces cerevisiae Jen1 lactate and Ady2 acetate transporters, including a phylogenetic analysis of 101 putative carboxylate transporters in twelve medically relevant Candida species. These proteins are assigned to distinct clades according to their amino acid sequence homology and represent the major carboxylic acid uptake systems in yeast. While Jen transporters belong to the sialate:H+ symporter (SHS) family, the Ady2 homologue members are assigned to the acetate uptake transporter (AceTr) family. Here, we reclassify the later members as ATO (acetate transporter ortholog). The new nomenclature will facilitate the study of these transporters, as well as the analysis of their relevance for Candida pathogenesis.
format	article
author	Rosana Alves Maria Sousa-Silva Daniel Vieira Pedro Soares Yasmin Chebaro Michael C. Lorenz Margarida Casal Isabel Soares-Silva Sandra Paiva
author_facet	Rosana Alves Maria Sousa-Silva Daniel Vieira Pedro Soares Yasmin Chebaro Michael C. Lorenz Margarida Casal Isabel Soares-Silva Sandra Paiva
author_sort	Rosana Alves
title	Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
title_short	Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
title_full	Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
title_fullStr	Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
title_full_unstemmed	Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis
title_sort	carboxylic acid transporters in <italic toggle="yes">candida</italic> pathogenesis
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/e82f3331b61542e7a4fca764a74179c1
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Carboxylic Acid Transporters in <italic toggle="yes">Candida</italic> Pathogenesis

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