Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

Abstract As the application of graphene nanomaterials gets increasingly attractive in the field of tissue engineering and regenerative medicine, the long-term evaluation is necessary and urgent as to their biocompatibility and regenerative capacity in different tissue injuries, such as nerve, bone,...

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Autores principales:	Yun Qian, Xu Wang, Jialin Song, Wei Chen, Shuai Chen, Yi Jin, Yuanming Ouyang, Wei-En Yuan, Cunyi Fan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/e82f618c71f840fd82619c1861f3eb80
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spelling	oai:doaj.org-article:e82f618c71f840fd82619c1861f3eb802021-12-02T18:24:59ZPreclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds10.1038/s41536-021-00142-22057-3995https://doaj.org/article/e82f618c71f840fd82619c1861f3eb802021-06-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00142-2https://doaj.org/toc/2057-3995Abstract As the application of graphene nanomaterials gets increasingly attractive in the field of tissue engineering and regenerative medicine, the long-term evaluation is necessary and urgent as to their biocompatibility and regenerative capacity in different tissue injuries, such as nerve, bone, and heart. However, it still remains controversial about the potential biological effects of graphene on neuronal activity, especially after severe nerve injuries. In this study, we establish a lengthy peripheral nerve defect rat model and investigate the potential toxicity of layered graphene-loaded polycaprolactone scaffold after implantation during 18 months in vivo. In addition, we further identify possible biologically regenerative effects of this scaffold on myelination, axonal outgrowth, and locomotor function recovery. It is confirmed that graphene-based nanomaterials exert negligible toxicity and repair large nerve defects by dual regulation of Schwann cells and astroglia in the central and peripheral nervous systems. The findings enlighten the future of graphene nanomaterial as a key type of biomaterials for clinical translation in neuronal regeneration.Yun QianXu WangJialin SongWei ChenShuai ChenYi JinYuanming OuyangWei-En YuanCunyi FanNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Yun Qian Xu Wang Jialin Song Wei Chen Shuai Chen Yi Jin Yuanming Ouyang Wei-En Yuan Cunyi Fan Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
description	Abstract As the application of graphene nanomaterials gets increasingly attractive in the field of tissue engineering and regenerative medicine, the long-term evaluation is necessary and urgent as to their biocompatibility and regenerative capacity in different tissue injuries, such as nerve, bone, and heart. However, it still remains controversial about the potential biological effects of graphene on neuronal activity, especially after severe nerve injuries. In this study, we establish a lengthy peripheral nerve defect rat model and investigate the potential toxicity of layered graphene-loaded polycaprolactone scaffold after implantation during 18 months in vivo. In addition, we further identify possible biologically regenerative effects of this scaffold on myelination, axonal outgrowth, and locomotor function recovery. It is confirmed that graphene-based nanomaterials exert negligible toxicity and repair large nerve defects by dual regulation of Schwann cells and astroglia in the central and peripheral nervous systems. The findings enlighten the future of graphene nanomaterial as a key type of biomaterials for clinical translation in neuronal regeneration.
format	article
author	Yun Qian Xu Wang Jialin Song Wei Chen Shuai Chen Yi Jin Yuanming Ouyang Wei-En Yuan Cunyi Fan
author_facet	Yun Qian Xu Wang Jialin Song Wei Chen Shuai Chen Yi Jin Yuanming Ouyang Wei-En Yuan Cunyi Fan
author_sort	Yun Qian
title	Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
title_short	Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
title_full	Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
title_fullStr	Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
title_full_unstemmed	Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
title_sort	preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e82f618c71f840fd82619c1861f3eb80
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_version_	1718378070907289600

Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds

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