Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease

Abstract To characterize the new SARS-Co-V-2 related multisystem inflammatory syndrome in children (MIS-C) among Israeli children and to compare it with Kawasaki disease (KD). We compared, in two medical centers, the clinical and laboratory characteristics of MIS-C, KD and an intermediate group, whi...

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Autores principales:	Maskit Bar-Meir, Alex Guri, Max E. Godfrey, Avram R. Shack, Philip J. Hashkes, Ofra Goldzweig, Orli Megged
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e83219188fd34f9cae257c35046eb677
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spelling	oai:doaj.org-article:e83219188fd34f9cae257c35046eb6772021-12-02T16:14:47ZCharacterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease10.1038/s41598-021-93389-02045-2322https://doaj.org/article/e83219188fd34f9cae257c35046eb6772021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93389-0https://doaj.org/toc/2045-2322Abstract To characterize the new SARS-Co-V-2 related multisystem inflammatory syndrome in children (MIS-C) among Israeli children and to compare it with Kawasaki disease (KD). We compared, in two medical centers, the clinical and laboratory characteristics of MIS-C, KD and an intermediate group, which met the case definitions of both conditions. MIS-C patients were older, were more likely to be hypotensive, to have significant gastrointestinal symptoms, lymphopenia and thrombocytopenia and to have non-coronary abnormal findings in their echocardiogram. Lymphopenia was an independent predictor of MIS-C. Most of our MIS-C patients responded promptly to corticosteroid therapy. KD incidence in both centers was similar in 2019 and 2020. Although there is clinical overlap between KD and MIS-C, these are separate entities. Lymphopenia clearly differentiates between these entities. MIS-C patients may benefit from corticosteroids as first-line therapy.Maskit Bar-MeirAlex GuriMax E. GodfreyAvram R. ShackPhilip J. HashkesOfra GoldzweigOrli MeggedNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maskit Bar-Meir Alex Guri Max E. Godfrey Avram R. Shack Philip J. Hashkes Ofra Goldzweig Orli Megged Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
description	Abstract To characterize the new SARS-Co-V-2 related multisystem inflammatory syndrome in children (MIS-C) among Israeli children and to compare it with Kawasaki disease (KD). We compared, in two medical centers, the clinical and laboratory characteristics of MIS-C, KD and an intermediate group, which met the case definitions of both conditions. MIS-C patients were older, were more likely to be hypotensive, to have significant gastrointestinal symptoms, lymphopenia and thrombocytopenia and to have non-coronary abnormal findings in their echocardiogram. Lymphopenia was an independent predictor of MIS-C. Most of our MIS-C patients responded promptly to corticosteroid therapy. KD incidence in both centers was similar in 2019 and 2020. Although there is clinical overlap between KD and MIS-C, these are separate entities. Lymphopenia clearly differentiates between these entities. MIS-C patients may benefit from corticosteroids as first-line therapy.
format	article
author	Maskit Bar-Meir Alex Guri Max E. Godfrey Avram R. Shack Philip J. Hashkes Ofra Goldzweig Orli Megged
author_facet	Maskit Bar-Meir Alex Guri Max E. Godfrey Avram R. Shack Philip J. Hashkes Ofra Goldzweig Orli Megged
author_sort	Maskit Bar-Meir
title	Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
title_short	Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
title_full	Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
title_fullStr	Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
title_full_unstemmed	Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease
title_sort	characterizing the differences between multisystem inflammatory syndrome in children and kawasaki disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e83219188fd34f9cae257c35046eb677
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Characterizing the differences between multisystem inflammatory syndrome in children and Kawasaki disease

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