CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT

Abstract. Many parts of immune system are involved in interaction of M. tuberculosis and human organism. There are some publications concerning significance of interferon and other cytokines in lung tuberculosis. Our research group investigated condition of interferon and cytokines systems in patien...

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Autores principales:	M. V. Mezentseva, V. A. Stakhanov, M. V. Zakharova, I. F. Zotova, M. I. Tregubova, I. M. Shapoval
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	infiltrative pulmonary tuberculosis immunity cytokines interleykines interferon Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/e8321c49b5b4442b98922a5a52f036a9
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spelling	oai:doaj.org-article:e8321c49b5b4442b98922a5a52f036a92021-11-22T07:09:45ZCYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT2220-76192313-739810.15789/2220-7619-2011-4-367-372https://doaj.org/article/e8321c49b5b4442b98922a5a52f036a92014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/71https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. Many parts of immune system are involved in interaction of M. tuberculosis and human organism. There are some publications concerning significance of interferon and other cytokines in lung tuberculosis. Our research group investigated condition of interferon and cytokines systems in patients with firstly detected infiltrative lung tuberculosis. The results of this study have shown direct links between clinical and immunological efficacy of the complex treatment of such patients. The active expression of IL-6 gene correlates with slow dynamics of lung infiltrate resolution and long saving of patient’s complaint for respiratory tract symptoms during the treatment. The expression of IL-12 gene linked to small volume of infiltrates in lung tissue before treatment whereas expression of IL-1β gene correlates with decrease of intoxication time and respiratory symptoms in patients during therapy. The knowledge about violation in cytokine regulation parts is absolutely necessary to determine dynamics of diseases development and treatment efficacy as well as to use immunotherapy.M. V. MezentsevaV. A. StakhanovM. V. ZakharovaI. F. ZotovaM. I. TregubovaI. M. ShapovalSankt-Peterburg : NIIÈM imeni Pasteraarticleinfiltrative pulmonary tuberculosisimmunitycytokinesinterleykinesinterferonInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 1, Iss 4, Pp 367-372 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	infiltrative pulmonary tuberculosis immunity cytokines interleykines interferon Infectious and parasitic diseases RC109-216
spellingShingle	infiltrative pulmonary tuberculosis immunity cytokines interleykines interferon Infectious and parasitic diseases RC109-216 M. V. Mezentseva V. A. Stakhanov M. V. Zakharova I. F. Zotova M. I. Tregubova I. M. Shapoval CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
description	Abstract. Many parts of immune system are involved in interaction of M. tuberculosis and human organism. There are some publications concerning significance of interferon and other cytokines in lung tuberculosis. Our research group investigated condition of interferon and cytokines systems in patients with firstly detected infiltrative lung tuberculosis. The results of this study have shown direct links between clinical and immunological efficacy of the complex treatment of such patients. The active expression of IL-6 gene correlates with slow dynamics of lung infiltrate resolution and long saving of patient’s complaint for respiratory tract symptoms during the treatment. The expression of IL-12 gene linked to small volume of infiltrates in lung tissue before treatment whereas expression of IL-1β gene correlates with decrease of intoxication time and respiratory symptoms in patients during therapy. The knowledge about violation in cytokine regulation parts is absolutely necessary to determine dynamics of diseases development and treatment efficacy as well as to use immunotherapy.
format	article
author	M. V. Mezentseva V. A. Stakhanov M. V. Zakharova I. F. Zotova M. I. Tregubova I. M. Shapoval
author_facet	M. V. Mezentseva V. A. Stakhanov M. V. Zakharova I. F. Zotova M. I. Tregubova I. M. Shapoval
author_sort	M. V. Mezentseva
title	CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
title_short	CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
title_full	CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
title_fullStr	CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
title_full_unstemmed	CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT
title_sort	cytokines as markers of the infiltrative pulmonary tuberculosis development
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/e8321c49b5b4442b98922a5a52f036a9
work_keys_str_mv	AT mvmezentseva cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment AT vastakhanov cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment AT mvzakharova cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment AT ifzotova cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment AT mitregubova cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment AT imshapoval cytokinesasmarkersoftheinfiltrativepulmonarytuberculosisdevelopment
_version_	1718418077265166336

CYTOKINES AS MARKERS OF THE INFILTRATIVE PULMONARY TUBERCULOSIS DEVELOPMENT

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