Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

During cortical development the first wave of oligodendrocyte precursor cells (OPCs) completely disappear by programmed cell death, so that it is presumed that this OPC population does not play a role at postnatal stages. In this study, authors use lineage tracing in different transgenic mice to sho...

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Autores principales:	David Orduz, Najate Benamer, Domiziana Ortolani, Eva Coppola, Lisa Vigier, Alessandra Pierani, María Cecilia Angulo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e834776c77214421b63a8800003a716f
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spelling	oai:doaj.org-article:e834776c77214421b63a8800003a716f2021-12-02T16:57:42ZDevelopmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis10.1038/s41467-019-11904-42041-1723https://doaj.org/article/e834776c77214421b63a8800003a716f2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11904-4https://doaj.org/toc/2041-1723During cortical development the first wave of oligodendrocyte precursor cells (OPCs) completely disappear by programmed cell death, so that it is presumed that this OPC population does not play a role at postnatal stages. In this study, authors use lineage tracing in different transgenic mice to show that a subpopulation of OPCs from the first wave survives at postnatal stages and display a preferential synaptic connectivity with their ontogenetically-related interneurons compared to other OPCs or interneuronsDavid OrduzNajate BenamerDomiziana OrtolaniEva CoppolaLisa VigierAlessandra PieraniMaría Cecilia AnguloNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David Orduz Najate Benamer Domiziana Ortolani Eva Coppola Lisa Vigier Alessandra Pierani María Cecilia Angulo Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
description	During cortical development the first wave of oligodendrocyte precursor cells (OPCs) completely disappear by programmed cell death, so that it is presumed that this OPC population does not play a role at postnatal stages. In this study, authors use lineage tracing in different transgenic mice to show that a subpopulation of OPCs from the first wave survives at postnatal stages and display a preferential synaptic connectivity with their ontogenetically-related interneurons compared to other OPCs or interneurons
format	article
author	David Orduz Najate Benamer Domiziana Ortolani Eva Coppola Lisa Vigier Alessandra Pierani María Cecilia Angulo
author_facet	David Orduz Najate Benamer Domiziana Ortolani Eva Coppola Lisa Vigier Alessandra Pierani María Cecilia Angulo
author_sort	David Orduz
title	Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
title_short	Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
title_full	Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
title_fullStr	Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
title_full_unstemmed	Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
title_sort	developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e834776c77214421b63a8800003a716f
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Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis

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