A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.

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Autores principales:	Bhairab N. Singh, Naoko Koyano-Nakagawa, Wuming Gong, Ivan P. Moskowitz, Cyprian V. Weaver, Elizabeth Braunlin, Satyabrata Das, Jop H. van Berlo, Mary G. Garry, Daniel J. Garry
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e834b139d7d24de2a7e908969edba69b
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spelling	oai:doaj.org-article:e834b139d7d24de2a7e908969edba69b2021-12-02T17:31:27ZA conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human10.1038/s41467-018-06617-z2041-1723https://doaj.org/article/e834b139d7d24de2a7e908969edba69b2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06617-zhttps://doaj.org/toc/2041-1723Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.Bhairab N. SinghNaoko Koyano-NakagawaWuming GongIvan P. MoskowitzCyprian V. WeaverElizabeth BraunlinSatyabrata DasJop H. van BerloMary G. GarryDaniel J. GarryNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bhairab N. Singh Naoko Koyano-Nakagawa Wuming Gong Ivan P. Moskowitz Cyprian V. Weaver Elizabeth Braunlin Satyabrata Das Jop H. van Berlo Mary G. Garry Daniel J. Garry A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
description	Due to the limited proliferation capacity of adult mammalian cardiomyocytes, the human heart has negligible regenerative capacity after injury. Here the authors show that a Hedgehog-Gli1-Mycn signaling cascade regulates cardiomyocyte proliferation and cardiac regeneration from amphibians to mammals.
format	article
author	Bhairab N. Singh Naoko Koyano-Nakagawa Wuming Gong Ivan P. Moskowitz Cyprian V. Weaver Elizabeth Braunlin Satyabrata Das Jop H. van Berlo Mary G. Garry Daniel J. Garry
author_facet	Bhairab N. Singh Naoko Koyano-Nakagawa Wuming Gong Ivan P. Moskowitz Cyprian V. Weaver Elizabeth Braunlin Satyabrata Das Jop H. van Berlo Mary G. Garry Daniel J. Garry
author_sort	Bhairab N. Singh
title	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
title_short	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
title_full	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
title_fullStr	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
title_full_unstemmed	A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
title_sort	conserved hh-gli1-mycn network regulates heart regeneration from newt to human
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e834b139d7d24de2a7e908969edba69b
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A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

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