LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling
The implications of long intergenic non-coding RNAs (lincRNAs) on cancer metabolism is unclear. Here, the authors identify that LINC00842 binds to PGC-1α and prevents PGC-1α from deacetylation by SIRT1, resulting in a metabolic reprogramming in pancreatic cancer cells.
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Nature Portfolio
2021
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oai:doaj.org-article:e834e5ba91294562923a00b8e12393062021-12-02T18:02:41ZLINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling10.1038/s41467-021-23904-42041-1723https://doaj.org/article/e834e5ba91294562923a00b8e12393062021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23904-4https://doaj.org/toc/2041-1723The implications of long intergenic non-coding RNAs (lincRNAs) on cancer metabolism is unclear. Here, the authors identify that LINC00842 binds to PGC-1α and prevents PGC-1α from deacetylation by SIRT1, resulting in a metabolic reprogramming in pancreatic cancer cells.Xudong HuangLing PanZhixiang ZuoMei LiLingxing ZengRui LiYing YeJialiang ZhangGuandi WuRuihong BaiLisha ZhuangLusheng WeiYanfen ZhengJiachun SuJunge DengShuang DengShaoping ZhangShihao ZhuXu CheChengfeng WangChen WuRufu ChenDongxin LinJian ZhengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xudong Huang Ling Pan Zhixiang Zuo Mei Li Lingxing Zeng Rui Li Ying Ye Jialiang Zhang Guandi Wu Ruihong Bai Lisha Zhuang Lusheng Wei Yanfen Zheng Jiachun Su Junge Deng Shuang Deng Shaoping Zhang Shihao Zhu Xu Che Chengfeng Wang Chen Wu Rufu Chen Dongxin Lin Jian Zheng LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| description |
The implications of long intergenic non-coding RNAs (lincRNAs) on cancer metabolism is unclear. Here, the authors identify that LINC00842 binds to PGC-1α and prevents PGC-1α from deacetylation by SIRT1, resulting in a metabolic reprogramming in pancreatic cancer cells. |
| format |
article |
| author |
Xudong Huang Ling Pan Zhixiang Zuo Mei Li Lingxing Zeng Rui Li Ying Ye Jialiang Zhang Guandi Wu Ruihong Bai Lisha Zhuang Lusheng Wei Yanfen Zheng Jiachun Su Junge Deng Shuang Deng Shaoping Zhang Shihao Zhu Xu Che Chengfeng Wang Chen Wu Rufu Chen Dongxin Lin Jian Zheng |
| author_facet |
Xudong Huang Ling Pan Zhixiang Zuo Mei Li Lingxing Zeng Rui Li Ying Ye Jialiang Zhang Guandi Wu Ruihong Bai Lisha Zhuang Lusheng Wei Yanfen Zheng Jiachun Su Junge Deng Shuang Deng Shaoping Zhang Shihao Zhu Xu Che Chengfeng Wang Chen Wu Rufu Chen Dongxin Lin Jian Zheng |
| author_sort |
Xudong Huang |
| title |
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| title_short |
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| title_full |
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| title_fullStr |
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| title_full_unstemmed |
LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| title_sort |
linc00842 inactivates transcription co-regulator pgc-1α to promote pancreatic cancer malignancy through metabolic remodelling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e834e5ba91294562923a00b8e1239306 |
| work_keys_str_mv |
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