Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis

Abstract Development of distant metastasis is the main cause of deaths in prostate cancer (PCa) patients. Understanding the mechanism of PCa metastasis is of utmost importance to improve its prognosis. The role of exosomal long noncoding RNA (lncRNA) has been reported not yet fully understood in the...

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Autores principales:	Yongming Jiang, Hui Zhao, Yuxiao Chen, Kangjian Li, Tianjie Li, Jianheng Chen, Baiyu Zhang, Caifen Guo, Liangliang Qing, Jihong Shen, Xiaodong Liu, Peng Gu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/e8350b00d4fa428c88d4719c066e61e2
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spelling	oai:doaj.org-article:e8350b00d4fa428c88d4719c066e61e22021-12-05T12:04:29ZExosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis10.1038/s41419-021-04421-02041-4889https://doaj.org/article/e8350b00d4fa428c88d4719c066e61e22021-12-01T00:00:00Zhttps://doi.org/10.1038/s41419-021-04421-0https://doaj.org/toc/2041-4889Abstract Development of distant metastasis is the main cause of deaths in prostate cancer (PCa) patients. Understanding the mechanism of PCa metastasis is of utmost importance to improve its prognosis. The role of exosomal long noncoding RNA (lncRNA) has been reported not yet fully understood in the metastasis of PCa. Here, we discovered an exosomal lncRNA HOXD-AS1 is upregulated in castration resistant prostate cancer (CRPC) cell line derived exosomes and serum exosomes from metastatic PCa patients, which correlated with its tissue expression. Further investigation confirmed exosomal HOXD-AS1 promotes prostate cancer cell metastasis in vitro and in vivo by inducing metastasis associated phenotype. Mechanistically exosomal HOXD-AS1 was internalized directly by PCa cells, acting as competing endogenous RNA (ceRNA) to modulate the miR-361-5p/FOXM1 axis, therefore promoting PCa metastasis. In addition, we found that serum exosomal HOXD-AS1 was upregulated in metastatic PCa patients, especially those with high volume disease. And it is correlated closely with Gleason Score, distant and nodal metastasis, Prostatic specific antigen (PSA) recurrence free survival, and progression free survival (PFS). This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR-361-5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa.Yongming JiangHui ZhaoYuxiao ChenKangjian LiTianjie LiJianheng ChenBaiyu ZhangCaifen GuoLiangliang QingJihong ShenXiaodong LiuPeng GuNature Publishing GrouparticleCytologyQH573-671ENCell Death and Disease, Vol 12, Iss 12, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Yongming Jiang Hui Zhao Yuxiao Chen Kangjian Li Tianjie Li Jianheng Chen Baiyu Zhang Caifen Guo Liangliang Qing Jihong Shen Xiaodong Liu Peng Gu Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
description	Abstract Development of distant metastasis is the main cause of deaths in prostate cancer (PCa) patients. Understanding the mechanism of PCa metastasis is of utmost importance to improve its prognosis. The role of exosomal long noncoding RNA (lncRNA) has been reported not yet fully understood in the metastasis of PCa. Here, we discovered an exosomal lncRNA HOXD-AS1 is upregulated in castration resistant prostate cancer (CRPC) cell line derived exosomes and serum exosomes from metastatic PCa patients, which correlated with its tissue expression. Further investigation confirmed exosomal HOXD-AS1 promotes prostate cancer cell metastasis in vitro and in vivo by inducing metastasis associated phenotype. Mechanistically exosomal HOXD-AS1 was internalized directly by PCa cells, acting as competing endogenous RNA (ceRNA) to modulate the miR-361-5p/FOXM1 axis, therefore promoting PCa metastasis. In addition, we found that serum exosomal HOXD-AS1 was upregulated in metastatic PCa patients, especially those with high volume disease. And it is correlated closely with Gleason Score, distant and nodal metastasis, Prostatic specific antigen (PSA) recurrence free survival, and progression free survival (PFS). This sheds a new insight into the regulation of PCa distant metastasis by exosomal HOXD-AS1 mediated miR-361-5p/FOXM1 axis, and provided a promising liquid biopsy biomarker to guide the detection and treatment of metastatic PCa.
format	article
author	Yongming Jiang Hui Zhao Yuxiao Chen Kangjian Li Tianjie Li Jianheng Chen Baiyu Zhang Caifen Guo Liangliang Qing Jihong Shen Xiaodong Liu Peng Gu
author_facet	Yongming Jiang Hui Zhao Yuxiao Chen Kangjian Li Tianjie Li Jianheng Chen Baiyu Zhang Caifen Guo Liangliang Qing Jihong Shen Xiaodong Liu Peng Gu
author_sort	Yongming Jiang
title	Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
title_short	Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
title_full	Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
title_fullStr	Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
title_full_unstemmed	Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis
title_sort	exosomal long noncoding rna hoxd-as1 promotes prostate cancer metastasis via mir-361-5p/foxm1 axis
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/e8350b00d4fa428c88d4719c066e61e2
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Exosomal long noncoding RNA HOXD-AS1 promotes prostate cancer metastasis via miR-361-5p/FOXM1 axis

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