Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies

Alzheimer’s and Parkinson’s diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins...

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Autores principales:	Jinwen Jiang, Yu Liu, Qihui Wu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Alzheimer’s disease Parkinson’s disease Aβ cascade hypothesis α-synuclein aggregation and spreading transcriptomics of nervous system Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/e8377e6943bc4f20a5b313a2c8875b70
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spelling	oai:doaj.org-article:e8377e6943bc4f20a5b313a2c8875b702021-11-18T06:01:29ZRevisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies1662-453X10.3389/fnins.2021.781722https://doaj.org/article/e8377e6943bc4f20a5b313a2c8875b702021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.781722/fullhttps://doaj.org/toc/1662-453XAlzheimer’s and Parkinson’s diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of Aβ and α-synuclein in mediating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases.Jinwen JiangYu LiuQihui WuFrontiers Media S.A.articleAlzheimer’s diseaseParkinson’s diseaseAβ cascade hypothesisα-synuclein aggregation and spreadingtranscriptomics of nervous systemNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Alzheimer’s disease Parkinson’s disease Aβ cascade hypothesis α-synuclein aggregation and spreading transcriptomics of nervous system Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Alzheimer’s disease Parkinson’s disease Aβ cascade hypothesis α-synuclein aggregation and spreading transcriptomics of nervous system Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Jinwen Jiang Yu Liu Qihui Wu Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
description	Alzheimer’s and Parkinson’s diseases (AD and PD) are amongst top of the prevalent neurodegenerative disease. One-third of PD patients are diagnosed with dementia, a pre-symptom of AD, but the underlying mechanism is elusive. Amyloid beta (Aβ) and α-synuclein are two of the most investigated proteins, whose pathological aggregation and spreading are crucial to the pathogenesis of AD and PD, respectively. Transcriptomic studies of the mammalian central nervous system shed light on gene expression profiles at molecular levels, regarding the complexity of neuronal morphologies and electrophysiological inputs/outputs. In the last decade, the booming of the single-cell RNA sequencing technique helped to understand gene expression patterns, alternative splicing, novel transcripts, and signal pathways in the nervous system at single-cell levels, providing insight for molecular taxonomy and mechanistic targets of the degenerative nervous system. Here, we re-visited the cell-cell transmission mechanisms of Aβ and α-synuclein in mediating disease propagation, and summarized recent single-cell transcriptome sequencing from different perspectives and discussed its understanding of neurodegenerative diseases.
format	article
author	Jinwen Jiang Yu Liu Qihui Wu
author_facet	Jinwen Jiang Yu Liu Qihui Wu
author_sort	Jinwen Jiang
title	Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
title_short	Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
title_full	Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
title_fullStr	Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
title_full_unstemmed	Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies
title_sort	revisit the cellular transmission and emerging techniques in understanding the mechanisms of proteinopathies
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e8377e6943bc4f20a5b313a2c8875b70
work_keys_str_mv	AT jinwenjiang revisitthecellulartransmissionandemergingtechniquesinunderstandingthemechanismsofproteinopathies AT yuliu revisitthecellulartransmissionandemergingtechniquesinunderstandingthemechanismsofproteinopathies AT qihuiwu revisitthecellulartransmissionandemergingtechniquesinunderstandingthemechanismsofproteinopathies
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Revisit the Cellular Transmission and Emerging Techniques in Understanding the Mechanisms of Proteinopathies

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