Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with...

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Autores principales:	Boshen Gong, Chuyuan Wang, Fanrui Meng, Haoyu Wang, Bo Song, Yang Yang, Zhongyan Shan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autoimmune thyroid disease gut microbiota Hashimoto thyroiditis (HT) Graves’ disease (GD) meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/e838c86a7d2b41beb9ebeec66d3f75ea
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spelling	oai:doaj.org-article:e838c86a7d2b41beb9ebeec66d3f75ea2021-11-17T06:09:41ZAssociation Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis1664-239210.3389/fendo.2021.774362https://doaj.org/article/e838c86a7d2b41beb9ebeec66d3f75ea2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.774362/fullhttps://doaj.org/toc/1664-2392BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.Boshen GongChuyuan WangFanrui MengHaoyu WangBo SongYang YangZhongyan ShanFrontiers Media S.A.articleautoimmune thyroid diseasegut microbiotaHashimoto thyroiditis (HT)Graves’ disease (GD)meta-analysisDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoimmune thyroid disease gut microbiota Hashimoto thyroiditis (HT) Graves’ disease (GD) meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	autoimmune thyroid disease gut microbiota Hashimoto thyroiditis (HT) Graves’ disease (GD) meta-analysis Diseases of the endocrine glands. Clinical endocrinology RC648-665 Boshen Gong Chuyuan Wang Fanrui Meng Haoyu Wang Bo Song Yang Yang Zhongyan Shan Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
description	BackgroundAutoimmune thyroid disease (AITD) is characterized by thyroid dysfunction and deficits in the autoimmune system. Growing attention has been paid toward the field of gut microbiota over the last few decades. Several recent studies have found that gut microbiota composition in patients with AITD has altered, but no studies have conducted systematic reviews on the association between gut microbiota and ATID.MethodsWe searched PubMed, Web of Science, Embase, and Cochrane databases without language restrictions and conducted a systematic review and meta-analysis of eight studies, including 196 patients with AITD.ResultsThe meta-analysis showed that the alpha diversity and abundance of certain gut microbiota were changed in patients with AITD compared to the controls. Chao1,the index of the microflora richness, was increased in the Hashimoto’s thyroiditis group compared to controls (SMD, 0.68, 95%CI: 0.16 to 1.20), while it was decreased in the Graves’ disease group (SMD, -0.87, 95%CI: -1.46 to -0.28). In addition, we found that some beneficial bacteria like Bifidobacterium and Lactobacillus were decreased in the AITD group, and harmful microbiota like Bacteroides fragilis was significantly increased compared with the controls. Furthermore, the percentage of relevant abundance of other commensal bacteria such as Bacteroidetes, Bacteroides, and Lachnospiraceae was increased compared with the controls.ConclusionsThis meta-analysis indicates an association between AITD and alteration of microbiota composition at the family, genus, and species levels.Systematic Review RegistrationPROSPERO, identifier CRD42021251557.
format	article
author	Boshen Gong Chuyuan Wang Fanrui Meng Haoyu Wang Bo Song Yang Yang Zhongyan Shan
author_facet	Boshen Gong Chuyuan Wang Fanrui Meng Haoyu Wang Bo Song Yang Yang Zhongyan Shan
author_sort	Boshen Gong
title	Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
title_short	Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
title_full	Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
title_fullStr	Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
title_full_unstemmed	Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis
title_sort	association between gut microbiota and autoimmune thyroid disease: a systematic review and meta-analysis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e838c86a7d2b41beb9ebeec66d3f75ea
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Association Between Gut Microbiota and Autoimmune Thyroid Disease: A Systematic Review and Meta-Analysis

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