B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcino...

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Autores principales:	Ayana T. Ruffin, Anthony R. Cillo, Tracy Tabib, Angen Liu, Sayali Onkar, Sheryl R. Kunning, Caleb Lampenfeld, Huda I. Atiya, Irina Abecassis, Cornelius H. L. Kürten, Zengbiao Qi, Ryan Soose, Umamaheswar Duvvuri, Seungwon Kim, Steffi Oesterrich, Robert Lafyatis, Lan G. Coffman, Robert L. Ferris, Dario A. A. Vignali, Tullia C. Bruno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e83ecb50387b47eaba497a672e531424
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spelling	oai:doaj.org-article:e83ecb50387b47eaba497a672e5314242021-12-02T17:52:38ZB cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma10.1038/s41467-021-23355-x2041-1723https://doaj.org/article/e83ecb50387b47eaba497a672e5314242021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23355-xhttps://doaj.org/toc/2041-1723Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival.Ayana T. RuffinAnthony R. CilloTracy TabibAngen LiuSayali OnkarSheryl R. KunningCaleb LampenfeldHuda I. AtiyaIrina AbecassisCornelius H. L. KürtenZengbiao QiRyan SooseUmamaheswar DuvvuriSeungwon KimSteffi OesterrichRobert LafyatisLan G. CoffmanRobert L. FerrisDario A. A. VignaliTullia C. BrunoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ayana T. Ruffin Anthony R. Cillo Tracy Tabib Angen Liu Sayali Onkar Sheryl R. Kunning Caleb Lampenfeld Huda I. Atiya Irina Abecassis Cornelius H. L. Kürten Zengbiao Qi Ryan Soose Umamaheswar Duvvuri Seungwon Kim Steffi Oesterrich Robert Lafyatis Lan G. Coffman Robert L. Ferris Dario A. A. Vignali Tullia C. Bruno B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
description	Recent studies have highlighted the importance of B cells and tertiary lymphoid structures (TLS) in the modulation of anti-tumor immune responses. Here, the authors characterize how HPV status influences the phenotype of tumor infiltrating B cells in patients with head and neck squamous cell carcinoma and demonstrate that TLS with germinal centres are associated with better survival.
format	article
author	Ayana T. Ruffin Anthony R. Cillo Tracy Tabib Angen Liu Sayali Onkar Sheryl R. Kunning Caleb Lampenfeld Huda I. Atiya Irina Abecassis Cornelius H. L. Kürten Zengbiao Qi Ryan Soose Umamaheswar Duvvuri Seungwon Kim Steffi Oesterrich Robert Lafyatis Lan G. Coffman Robert L. Ferris Dario A. A. Vignali Tullia C. Bruno
author_facet	Ayana T. Ruffin Anthony R. Cillo Tracy Tabib Angen Liu Sayali Onkar Sheryl R. Kunning Caleb Lampenfeld Huda I. Atiya Irina Abecassis Cornelius H. L. Kürten Zengbiao Qi Ryan Soose Umamaheswar Duvvuri Seungwon Kim Steffi Oesterrich Robert Lafyatis Lan G. Coffman Robert L. Ferris Dario A. A. Vignali Tullia C. Bruno
author_sort	Ayana T. Ruffin
title	B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
title_short	B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
title_full	B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
title_fullStr	B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
title_full_unstemmed	B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
title_sort	b cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e83ecb50387b47eaba497a672e531424
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B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma

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