Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/e8406da68d1441ed800979ff78505b90 |
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| Sumario: | Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-induced impairment of intestinal stem cells aggravates intestinal inflammation via miRNA. |
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