Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-...

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Autores principales:	Lele Song, Renxu Chang, Xia Sun, Liying Lu, Han Gao, Huiying Lu, Ritian Lin, Xiaorong Xu, Zhanju Liu, Lixing Zhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e8406da68d1441ed800979ff78505b90
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:e8406da68d1441ed800979ff78505b902021-12-02T14:21:58ZMacrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice10.1038/s42003-021-01730-02399-3642https://doaj.org/article/e8406da68d1441ed800979ff78505b902021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01730-0https://doaj.org/toc/2399-3642Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-induced impairment of intestinal stem cells aggravates intestinal inflammation via miRNA.Lele SongRenxu ChangXia SunLiying LuHan GaoHuiying LuRitian LinXiaorong XuZhanju LiuLixing ZhanNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Lele Song Renxu Chang Xia Sun Liying Lu Han Gao Huiying Lu Ritian Lin Xiaorong Xu Zhanju Liu Lixing Zhan Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
description	Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in colitis crypts. This study illustrates how macrophage-induced impairment of intestinal stem cells aggravates intestinal inflammation via miRNA.
format	article
author	Lele Song Renxu Chang Xia Sun Liying Lu Han Gao Huiying Lu Ritian Lin Xiaorong Xu Zhanju Liu Lixing Zhan
author_facet	Lele Song Renxu Chang Xia Sun Liying Lu Han Gao Huiying Lu Ritian Lin Xiaorong Xu Zhanju Liu Lixing Zhan
author_sort	Lele Song
title	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
title_short	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
title_full	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
title_fullStr	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
title_full_unstemmed	Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice
title_sort	macrophage-derived eda-a2 inhibits intestinal stem cells by targeting mir-494/eda2r/β-catenin signaling in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e8406da68d1441ed800979ff78505b90
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Macrophage-derived EDA-A2 inhibits intestinal stem cells by targeting miR-494/EDA2R/β-catenin signaling in mice

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