Influence of endocrine disease on l‐lactate concentrations in blood of ponies

Abstract Background Blood l‐lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l‐lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumna...

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Autores principales:	Bettina Dunkel, Edward J. Knowles, Yu‐Mei Chang, Nicola J. Menzies‐Gow
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	adiposity equine insulin resistance l‐lactate metabolism pituitary pars intermedia dysfunction Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/e8417e77feed4e4d860a31bdee90df2f
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spelling	oai:doaj.org-article:e8417e77feed4e4d860a31bdee90df2f2021-11-30T17:01:05ZInfluence of endocrine disease on l‐lactate concentrations in blood of ponies1939-16760891-664010.1111/jvim.16079https://doaj.org/article/e8417e77feed4e4d860a31bdee90df2f2021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16079https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background Blood l‐lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l‐lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals Systemically healthy client‐owned ponies (n = 101). Methods Prospective case‐control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l‐lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l‐lactate and variables of endocrine health were determined. Results Using a seasonal cutoff point of ACTH concentrations ≥47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 μiU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 μiU/mL, 57 ponies had ID and 37 did not. Blood l‐lactate concentrations were significantly lower in obese (average body condition score ≥ 7/9) compared to nonobese ponies (0.6 mmol/L; range, 0.0‐1.9 mmol/L vs 0.8 mmol/L; range, 0.3‐2.7 mmol/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7 mmol/L; range, 0.0‐2.7 mmol/L vs 0.7 mmol/L; range, 0.3‐1.8 mmol/L; P = .84) and with and without ID (0.7 mmol/L; range, 0.3‐2.7 mmol/L vs 0.8 mmol/L; range, 0.0‐1.6 mmol/L; P = .63). Conclusions and Clinical Importance Results do not support an effect of endocrine status on l‐lactate concentrations in blood of ponies.Bettina DunkelEdward J. KnowlesYu‐Mei ChangNicola J. Menzies‐GowWileyarticleadiposityequineinsulin resistancel‐lactate metabolismpituitary pars intermedia dysfunctionVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1582-1588 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adiposity equine insulin resistance l‐lactate metabolism pituitary pars intermedia dysfunction Veterinary medicine SF600-1100
spellingShingle	adiposity equine insulin resistance l‐lactate metabolism pituitary pars intermedia dysfunction Veterinary medicine SF600-1100 Bettina Dunkel Edward J. Knowles Yu‐Mei Chang Nicola J. Menzies‐Gow Influence of endocrine disease on l‐lactate concentrations in blood of ponies
description	Abstract Background Blood l‐lactate concentrations are higher in people with developing or established diabetes mellitus and insulin resistance. Objectives To investigate whether blood l‐lactate concentrations are positively correlated with measures of insulin dysregulation (ID) or increased autumnal ACTH concentrations in ponies. Animals Systemically healthy client‐owned ponies (n = 101). Methods Prospective case‐control study. Blood samples were obtained from 101 clinically healthy ponies. Breed, weight, height, and subjective and objective measures of body condition were recorded. Blood l‐lactate, glucose, triglyceride, total adiponectin, and ACTH concentrations were measured and an oral sugar test (OST) was carried out. Correlations between blood l‐lactate and variables of endocrine health were determined. Results Using a seasonal cutoff point of ACTH concentrations ≥47 pg/mL, 55 ponies had increased autumnal ACTH concentrations and 45 did not. Using a basal insulin concentration of >50 μiU/mL, 42 ponies were diagnosed with ID and 58 were not. Using a 60 minutes after OST cutoff point of >45 μiU/mL, 57 ponies had ID and 37 did not. Blood l‐lactate concentrations were significantly lower in obese (average body condition score ≥ 7/9) compared to nonobese ponies (0.6 mmol/L; range, 0.0‐1.9 mmol/L vs 0.8 mmol/L; range, 0.3‐2.7 mmol/L; P = .01). No other significant correlations were detected. No differences were detected between ponies with and without increased autumnal ACTH concentrations (0.7 mmol/L; range, 0.0‐2.7 mmol/L vs 0.7 mmol/L; range, 0.3‐1.8 mmol/L; P = .84) and with and without ID (0.7 mmol/L; range, 0.3‐2.7 mmol/L vs 0.8 mmol/L; range, 0.0‐1.6 mmol/L; P = .63). Conclusions and Clinical Importance Results do not support an effect of endocrine status on l‐lactate concentrations in blood of ponies.
format	article
author	Bettina Dunkel Edward J. Knowles Yu‐Mei Chang Nicola J. Menzies‐Gow
author_facet	Bettina Dunkel Edward J. Knowles Yu‐Mei Chang Nicola J. Menzies‐Gow
author_sort	Bettina Dunkel
title	Influence of endocrine disease on l‐lactate concentrations in blood of ponies
title_short	Influence of endocrine disease on l‐lactate concentrations in blood of ponies
title_full	Influence of endocrine disease on l‐lactate concentrations in blood of ponies
title_fullStr	Influence of endocrine disease on l‐lactate concentrations in blood of ponies
title_full_unstemmed	Influence of endocrine disease on l‐lactate concentrations in blood of ponies
title_sort	influence of endocrine disease on l‐lactate concentrations in blood of ponies
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e8417e77feed4e4d860a31bdee90df2f
work_keys_str_mv	AT bettinadunkel influenceofendocrinediseaseonllactateconcentrationsinbloodofponies AT edwardjknowles influenceofendocrinediseaseonllactateconcentrationsinbloodofponies AT yumeichang influenceofendocrinediseaseonllactateconcentrationsinbloodofponies AT nicolajmenziesgow influenceofendocrinediseaseonllactateconcentrationsinbloodofponies
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Influence of endocrine disease on l‐lactate concentrations in blood of ponies

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